ERRβ/γ Antibody (E-1): sc-376449

ERRβ/γ Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ERRβ/γ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERRβ/γ (E-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ERRβ/γ proteins are orphan nuclear receptors that play a crucial role in regulating gene expression by binding to estrogen responsive elements (EREs), similar to estrogen receptors. ERRβ, also known as steroid hormone receptor ERR2 or estrogen receptor-like 2, is particularly important during mammary gland development and embryogenesis; absence of ERRβ can lead to severe defects in chorion formation, resulting in placental failure and embryonic death. Additionally, ERRγ, or ERR3, is predominantly expressed in the fetal heart, and loss of ERRγ can cause lactatemia and early neonatal mortality. ERRβ/γ′s ability to modulate transcriptional activity highlights significance in developmental processes and potential implications in reproductive health and heart function, making ERRβ/γ (E-1) monoclonal antibody an essential tool for researchers studying these critical biological pathways.

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ERRβ/γ Antibody (E-1) References:

1. Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.  |  Chen, F., et al. 1999. Gene. 228: 101-9. PMID: 10072763
2. Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3.  |  Hong, H., et al. 1999. J Biol Chem. 274: 22618-26. PMID: 10428842
3. Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.  |  Greschik, H., et al. 2002. Mol Cell. 9: 303-13. PMID: 11864604
4. Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.  |  Cheung, CP., et al. 2005. J Clin Endocrinol Metab. 90: 1830-44. PMID: 15598686
5. Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides.  |  Gearhart, MD., et al. 2005. Biochemistry. 44: 4196-203. PMID: 15766247
6. Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta.  |  Zhou, W., et al. 2006. J Clin Endocrinol Metab. 91: 569-79. PMID: 16332939
7. ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.  |  Zhou, W., et al. 2007. Mol Cell Endocrinol. 278: 52-62. PMID: 17920186
8. Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.  |  Chanda, D., et al. 2023. Proc Natl Acad Sci U S A. 120: e2219644120. PMID: 37155882
9. ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.  |  Jung, YS., et al. 2024. Redox Biol. 71: 103107. PMID: 38479224
10. Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells.  |  Adkins-Threats, M., et al. 2024. Cell Stem Cell. 31: 886-903.e8. PMID: 38733994
11. DY131 activates ERRγ/TFAM axis to protect against metabolic disorders and acute kidney injury.  |  Gong, W., et al. 2024. Clin Sci (Lond). 138: 777-795. PMID: 38860674
12. Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta.  |  Luo, J., et al. 1997. Nature. 388: 778-82. PMID: 9285590

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ERRβ/γ Antibody (E-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ERRβ/γ Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ERRβ/γ Antibody (E-1) Specifications

Alternate Product Name: ERRβ/γ

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 251-316

Epitope Target: ERRβ

Epitope Species: human

Product Reactivity/Detection: ERRβ and ERRγ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ERRβ/γ Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent