Date published: 2026-5-8

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ERK Inhibitor III (CAS 331656-92-9)

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Alternate Names:
1-nitro-2-[(Z)-[5-(3-nitrophenyl)furan-2-yl]methylideneamino]guanidine
Application:
ERK Inhibitor III is a cell-permeable, site-targeting inhibitor of ERK
CAS Number:
331656-92-9
Molecular Weight:
318.25
Molecular Formula:
C12H10N6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ERK Inhibitor III is a compound that functions by inhibiting the activity of the extracellular signal-regulated kinase (ERK) pathway. Erk Inhibitor Iii acts by targeting the ATP-binding site of ERK, preventing its phosphorylation and subsequent activation. By doing so, ERK Inhibitor III effectively disrupts the downstream signaling cascade mediated by ERK, leading to the inhibition of cellular processes such as proliferation, differentiation, and survival. Erk Inhibitor Iii exerts its mechanism of action by interfering with the phosphorylation of ERK, thereby modulating the activity of various transcription factors and gene expression. Through its targeted inhibition of the ERK pathway, ERK Inhibitor III is useful for investigating the specific roles of ERK signaling in cellular processes and for elucidating the molecular mechanisms underlying various physiological and pathological conditions.


ERK Inhibitor III (CAS 331656-92-9) References

  1. Cyclic AMP and mitogen-activated protein kinases are required for glutamate-dependent cyclic AMP response element binding protein and Elk-1 phosphorylation in the dorsal striatum in vivo.  |  Choe, ES. and McGinty, JF. 2001. J Neurochem. 76: 401-12. PMID: 11208903
  2. Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells.  |  Chang, W., et al. 2009. Exp Lung Res. 35: 324-43. PMID: 19415549
  3. Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation.  |  Leidi, M., et al. 2012. J Nutr Biochem. 23: 1224-9. PMID: 22209000
  4. In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.  |  Vancraenenbroeck, R., et al. 2014. Front Mol Neurosci. 7: 51. PMID: 24917786
  5. MEK-independent ERK activation in human neutrophils and its impact on functional responses.  |  Simard, FA., et al. 2015. J Leukoc Biol. 98: 565-73. PMID: 26243391
  6. The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C.  |  Loers, G., et al. 2017. J Neurochem. 142: 392-406. PMID: 28542923
  7. Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens.  |  Ursu, O., et al. 2017. PLoS One. 12: e0185650. PMID: 29023490
  8. Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan.  |  Theis, T., et al. 2018. Mol Neurobiol. 55: 8203-8215. PMID: 29520715
  9. Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways.  |  Chou, YT., et al. 2019. Carcinogenesis. 40: 461-473. PMID: 30418535
  10. Effects of L1 adhesion molecule agonistic mimetics on signal transduction in neuronal functions.  |  Nagaraj, V., et al. 2023. Biochem Biophys Res Commun. 642: 27-34. PMID: 36543021

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ERK Inhibitor III, 5 mg

sc-221595
5 mg
$200.00