ErbB4/HER4 Antibody (G-6): sc-514462

ErbB-4 Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects ErbB-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ErbB-4 plays a crucial role in cell signaling pathways that regulate cell proliferation and differentiation, making ErbB-4 a significant player in various physiological processes and a potential target in cancer research. ErbB-4 is primarily located in the cell membrane, where ErbB-4 functions as a receptor tyrosine kinase. Upon ligand binding, ErbB-4 can form homodimers or heterodimers with other members of the EGF receptor family, which is essential for initiating downstream signaling cascades that influence cellular responses. ErbB-4 expression is particularly high in breast carcinoma cell lines, as well as in normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum, highlighting ErbB-4′s importance in both normal physiology and disease states. Anti-ErbB-4 antibody (G-6) allows researchers to explore ErbB-4′s role in various biological contexts, including involvement in cancer progression and therapeutic resistance.

The preferred ErbB4/HER4 antibody is ErbB4/HER4 Antibody (C-7): sc-8050.