Molecular structure of ER 50891, CAS Number: 187400-85-7
ER 50891 (CAS 187400-85-7)
See product citations (2)
Alternate Names:
4-[5-[8-(1-Methylethyl)-4-phenyl-2- quinolinyl]-1H-pyrrolo-2-benzoic acid
Application:
ER 50891 is a RARα receptor antagonist
CAS Number:
187400-85-7
Molecular Weight:
432.51
Molecular Formula:
C29H24N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ER 50891 is classified as a quinoline derivative, an organic compound. It possesses strong inhibitory properties against the enzyme acetylcholinesterase (AChE), making it a valuable asset in scientific research and laboratory investigations. Specifically designed as a selective inhibitor, ER 50891 targets AChE, the enzyme responsible for breaking down acetylcholine, a neurotransmitter. By hindering AChE′s activity, ER 50891 effectively elevates the levels of acetylcholine.
ER 50891 (CAS 187400-85-7) References
- Retinoic acid-producing, ex-vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes. | Di Caro, V., et al. 2013. Clin Exp Immunol. 174: 302-17. PMID: 23865694
- Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. | Müller, P., et al. 2015. PLoS One. 10: e0131467. PMID: 26173116
- ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. | Clarke, CJ., et al. 2016. J Lipid Res. 57: 868-81. PMID: 27013100
- Retinoic acid induces hypersegmentation and enhances cytotoxicity of neutrophils against cancer cells. | Shrestha, S., et al. 2017. Immunol Lett. 182: 24-29. PMID: 28065603
- Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme. | Li, A., et al. 2017. Nat Commun. 8: ncomms14139. PMID: 28106042
- Testicular organoid generation by a novel in vitro three-layer gradient system. | Alves-Lopes, JP., et al. 2017. Biomaterials. 130: 76-89. PMID: 28364632
- All-trans retinoic acid and human salivary histatin-1 promote the spreading and osteogenic activities of pre-osteoblasts in vitro. | Sun, W., et al. 2020. FEBS Open Bio. 10: 396-406. PMID: 31957262
- The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation. | Wang, S., et al. 2020. Drug Des Devel Ther. 14: 297-308. PMID: 32158187
- Retinoic acid-responsive CD8 effector T cells are selectively increased in IL-23-rich tissue in gastrointestinal GVHD. | Ball, JA., et al. 2021. Blood. 137: 702-717. PMID: 32905596
- Retinoic Acid Sensitivity of Triple-Negative Breast Cancer Cells Characterized by Constitutive Activation of the notch1 Pathway: The Role of Rarβ. | Paroni, G., et al. 2020. Cancers (Basel). 12: PMID: 33081033
- Controlling neural territory patterning from pluripotency using a systems developmental biology approach. | Sears, KE., et al. 2022. iScience. 25: 104133. PMID: 35434550
- Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example. | Nyffeler, J., et al. 2022. Toxicol Appl Pharmacol. 444: 116032. PMID: 35483669
- Multivariate chemogenomic screening prioritizes new macrofilaricidal leads. | Wheeler, NJ., et al. 2023. Commun Biol. 6: 44. PMID: 36639423
Inhibitor of:
RARα, and Transcription Factor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ER 50891, 10 mg | sc-362733 | 10 mg | $259.00 | |||
ER 50891, 50 mg | sc-362733A | 50 mg | $1056.00 |