ER 50891 CAS: 187400-85-7
MF: C29H24N2O2
MW: 432.51
A RARα receptor antagonist.

ER 50891 (CAS 187400-85-7)

ER 50891 | CAS 187400-85-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 4-[5-[8-(1-Methylethyl)-4-phenyl-2- quinolinyl]-1H-pyrrolo-2-benzoic acid
Application: ER 50891 is a RARα receptor antagonist
CAS Number: 187400-85-7
Molecular Weight: 432.51
Molecular Formula: C29H24N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

ER 50891 is an antagonist of RARα receptors which displays selective affinity for RARα.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
296.53° C (Predicted)
Boiling Point :
660.85° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
RARα receptors: IC50 = 1.8 nM; RARγ: IC50 = 432 nM; RARβ: IC50 = 535 nM; HL-60: IC50 = 6.4 nM (human)
pK Values :
pKa: 4.20 (Predicted), pKb: 4.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10094345
MDL Number :
MFCD20926333
SMILES :
CC(C)C1=CC=CC2=C1N=C(C=C2C3=CC=CC=C3)C4=CC=C(N4)C5=CC=C(C=C5)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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ER 50891 (CAS 187400-85-7)  Product Citations

See how others have used ER 50891 (CAS 187400-85-7). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28065603  Shrestha, S. et al. 2017. Immunol. Lett. 182: 24-29.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Hou et al Hou et al. (PubMed ID 25364979) used the RAR antagonist ER50891 to confirm retinoic acid receptor- (RAR )'s role in the RA-induced neural differentiation of iPSCs. -SCBT Publication Review
Date published: 2015-06-02
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