Eppin Antibody (YY-23): sc-100726
- Eppin Antibody (YY-23) is a mouse monoclonal IgM Eppin antibody provided at 200 µl ascites
- raised against recombinant Eppin of human origin
- recommended for detection of Eppin of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Eppin Antibody (YY-23). This work is in progress.
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Eppin Antibody (YY-23) is a mouse monoclonal IgM antibody that detects Eppin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Eppin antibody (YY-23) is available as the non-conjugated monoclonal isotype antibody. Eppin, an epididymal protease inhibitor, plays a crucial role in male fertility by providing antimicrobial protection to spermatozoa. Eppin protein is primarily located in the epididymis and testis, where Eppin is secreted into the seminal plasma. Eppin′s presence in these locations is vital as Eppin binds to semenogelin, forming a complex that not only protects sperm from microbial attack but also aids in the preparation and survival of spermatozoa within the female reproductive tract. The gene encoding Eppin is situated on chromosome 20q12-q13 and is part of a cluster that includes several Eppin-like genes, highlighting Eppin′s evolutionary significance. Eppin (YY-23) antibody is an essential tool for researchers studying male reproductive health and the mechanisms underlying sperm function and protection.
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Eppin Antibody (YY-23) References:
- Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis. | Richardson, RT., et al. 2001. Gene. 270: 93-102. PMID: 11404006
- Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2. | Sivashanmugam, P., et al. 2003. Gene. 312: 125-34. PMID: 12909348
- Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif. | Yenugu, S., et al. 2004. Biol Reprod. 71: 1484-90. PMID: 15229136
- Association of eppin with semenogelin on human spermatozoa. | Wang, Z., et al. 2005. Biol Reprod. 72: 1064-70. PMID: 15590901
- Eppin: a candidate male contraceptive vaccine? | Karande, A. 2004. J Biosci. 29: 373-4. PMID: 15625390
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eppin Antibody (YY-23) | sc-100726 | 200 µl ascites | $339.00 |