Epoxyquinone G109 (racemic) (CAS 163972-12-1)

Epoxyquinone G109 (racemic) is a synthetic organic compound known for its role as a potent inhibitor of protein tyrosine phosphatases (PTPs). These enzymes are critical regulators of cellular signaling pathways, mediating the dephosphorylation of tyrosine residues on proteins. By inhibiting PTPs, Epoxyquinone G109 effectively modulates signal transduction processes that are essential for various cellular functions such as growth, differentiation, and metabolism. In scientific research, Epoxyquinone G109 is employed to study the regulation and dynamics of phosphotyrosine signaling networks. Researchers use this compound to dissect the roles of specific PTPs in cellular processes and to explore the effects of altered tyrosine phosphorylation on downstream signaling pathways. Techniques such as Western blotting, mass spectrometry, and phosphoproteomics are utilized to analyze the impact of Epoxyquinone G109 on protein phosphorylation profiles and to identify PTP substrates. Additionally, this inhibitor aids in the development of new strategies for modulating PTP activity, providing insights into the design of novel biochemical tools and potential agents. The racemic form of Epoxyquinone G109 is particularly valuable in understanding the stereochemical aspects of enzyme inhibition and the structure-activity relationships governing PTP interactions. Overall, Epoxyquinone G109 serves as a critical tool in the study of tyrosine phosphorylation and its regulatory mechanisms in cell signaling.