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Epostane (CAS 80471-63-2)

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Application:
Epostane is a 3β-Hydroxysteroid dehydrogenase inhibitor and a derivative of trilostane. Interceptive
CAS Number:
80471-63-2
Molecular Weight:
357.49
Molecular Formula:
C22H31NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Epostane, also referred to as 6-methyl-epi-androsterone, is a synthetic steroid hormone utilized in laboratory research to explore the biological impacts of steroid hormones. This compound is derived from testosterone and shares a structural resemblance with other androgens like dihydrotestosterone (DHT) and androstenedione. Its alternate names include 6-methyl-androstan-3-one-17-ol and 6-methyl-androstan-17-ol. Epostane has found applications in various scientific investigations, particularly in examining the effects of androgens on male reproductive organ development and function, brain development and function, cardiovascular system, immune system, and endocrine system. Its mechanism of action involves binding to androgen receptors, proteins located within the cytoplasm of cells. Upon binding, epostane initiates a cascade of biochemical events that stimulate the production of proteins and other molecules essential for the development and proper functioning of the target organs and systems.


Epostane (CAS 80471-63-2) References

  1. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.  |  Du, C., et al. 2000. Cell. 102: 33-42. PMID: 10929711
  2. Epostane and indomethacin actions on ovarian kallikrein and plasminogen activator activities during ovulation in the gonadotropin-primed immature rat.  |  Tanaka, N., et al. 1992. Biol Reprod. 46: 665-70. PMID: 1576264
  3. Effect of epostane, a competitive inhibitor of the 3beta-hydroxysteroid dehydrogenase enzyme, in cyclic sows.  |  Martin, PA., et al. 1988. Theriogenology. 30: 823-9. PMID: 16726523
  4. Increased ovulation rate in gilts after oral administration of epostane.  |  Fu, SL., et al. 1990. J Reprod Fertil. 90: 297-304. PMID: 2231549
  5. Effects of epostane on ovarian levels of progesterone, 17 beta-estradiol, prostaglandin E2, and prostaglandin F2 alpha during ovulation in the gonadotropin-primed immature rat.  |  Espey, LL., et al. 1990. Endocrinology. 127: 259-63. PMID: 2361472
  6. [Interceptive activity of epostane in pregnant rats and rhesus monkeys].  |  Liu, CG., et al. 1990. Zhongguo Yao Li Xue Bao. 11: 62-5. PMID: 2403018
  7. Effect of epostane, ZK 98299, and ZK 98734 on the interruption of pregnancy in the rat.  |  Snyder, BW., et al. 1989. Biol Reprod. 40: 549-54. PMID: 2758087
  8. Induction of parturition in swine and epostane, a competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase.  |  Martin, PA., et al. 1987. J Anim Sci. 64: 497-506. PMID: 3470276
  9. Win 32,729, a new, potent interceptive agent in rats and rhesus monkeys.  |  Creange, JE., et al. 1981. Contraception. 24: 289-99. PMID: 6273064
  10. Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds.  |  Christiansen, RG., et al. 1984. J Med Chem. 27: 928-31. PMID: 6330362
  11. [Antifertility effects of mifepristone and epostane alone and in combination in rats].  |  Liu, CG., et al. 1993. Zhongguo Yao Li Xue Bao. 14: 437-40. PMID: 8010036
  12. Potentiating effect of epostane on pregnancy terminating activity of RU 486 in the rat.  |  Vanage, G., et al. 1993. Contraception. 47: 499-506. PMID: 8513677
  13. A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro.  |  Han, Z., et al. 1997. J Biol Chem. 272: 13432-6. PMID: 9148968

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Epostane, 1 mg

sc-207627
1 mg
$372.00