Erythropoietin/EPO Antibody (7D10): sc-80995

Epo Antibody (7D10) is a mouse monoclonal IgG1 antibody that detects the Epo protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Epo antibody (7D10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Erythropoietin, or Epo, is a crucial glycoprotein composed of 165 amino acids, primarily synthesized in the kidneys, and plays a vital role in regulating erythropoiesis, the process of red blood cell formation. This regulation is particularly important during steady-state conditions and in response to blood loss or hemorrhage, ensuring adequate oxygen delivery throughout the body. Epo achieves this by stimulating the proliferation and maturation of erythroid precursor cells in the bone marrow. The Epo receptor, EpoR, is expressed on megakaryocytes, erythroid progenitors, and endothelial cells, facilitating the action of Epo. Dysregulation of Epo levels can lead to various pathophysiological conditions; for instance, overexpression is linked to polycythemia vera, characterized by the Epo-independent growth of erythrocytic progenitors from abnormal stem cells, while a deficiency in Epo is often associated with anemia of chronic disease, commonly seen in patients with rheumatoid arthritis.

The preferred Erythropoietin/EPO antibody is Erythropoietin/EPO Antibody (B-4): sc-5290.