(−)Epicatechin gallate (CAS 1257-08-5)
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(−)Epicatechin gallate is a polyphenol apoptosis inducer in tumor cells found in green tea. Studies suggest that (−)Epicatechin gallate causes anti-proliferative and anti-inflammatory effects on pancreatic ductal adenocarcinoma cells. Alternate studies show that (−)Epicatechin gallate can suppress H2O2-induced genotoxicity in vitro in C6 astroglial cells. In contrast at high concentrations polyphenols are shown to reverse the genoprotective effects that they produce at low concentrations. Furthermore, (−)Epicatechin gallate can inhibit the development of mouse blastocysts via apoptosis. Studies indicate that (−)Epicatechin gallate binds to the cell membrane in methicillin-resistant Staphylococcus aureus which decreases the fluidity of the bilayer and induces changes in gene expression. Also upon binding to penicillin-binding protein (PBP) 2a on the cell membrane of Staphylococcus aureus the membrane is sensitized to Oxacillin (sc-224180) and other beta-lactam agents.
(−)Epicatechin gallate (CAS 1257-08-5) References
- Flavonoid content of U.S. fruits, vegetables, and nuts. | Harnly, JM., et al. 2006. J Agric Food Chem. 54: 9966-77. PMID: 17177529
- Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. | Bernal, P., et al. 2010. J Biol Chem. 285: 24055-65. PMID: 20516078
- Epicatechin gallate decreases the viability and subsequent embryonic development of mouse blastocysts. | Tu, HC., et al. 2010. Taiwan J Obstet Gynecol. 49: 174-80. PMID: 20708524
- Genoprotective effects of the green tea-derived polyphenol/epicatechin gallate in C6 astroglial cells. | Abib, RT., et al. 2010. J Med Food. 13: 1111-5. PMID: 20828315
- Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. | Kürbitz, C., et al. 2011. Cancer Sci. 102: 728-34. PMID: 21241417
- Inhibitory effect of epicatechin gallate on protein glycation. | Wu, X., et al. 2019. Food Res Int. 122: 230-240. PMID: 31229076
- Synthesis of B-ring-fluorinated (-)-epicatechin gallate derivatives. | Thieltges, DDS., et al. 2020. Org Biomol Chem. 18: 4024-4028. PMID: 32427254
- Separation of epigallocatechin gallate and epicatechin gallate from tea polyphenols by macroporous resin and crystallization. | Wang, L., et al. 2021. Anal Methods. 13: 832-842. PMID: 33507177
- (-)-Epicatechin gallate blocks the development of atherosclerosis by regulating oxidative stress in vivo and in vitro. | Yu, J., et al. 2021. Food Funct. 12: 8715-8727. PMID: 34365492
- Epicatechin Gallate as Xanthine Oxidase Inhibitor: Inhibitory Kinetics, Binding Characteristics, Synergistic Inhibition, and Action Mechanism. | Zhu, M., et al. 2021. Foods. 10: PMID: 34574301
- Epicatechin gallate prevents the de novo synthesis of fatty acid and the migration of prostate cancer cells. | Chen, L., et al. 2021. Acta Biochim Biophys Sin (Shanghai). 53: 1662-1669. PMID: 34718375
- (-)-Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling. | Chen, G., et al. 2022. Arch Biochem Biophys. 729: 109393. PMID: 36084697
- Molecular mechanism of epicatechin gallate binding with carboxymethyl β-glucan and its effect on antibacterial activity. | Wang, J., et al. 2022. Carbohydr Polym. 298: 120105. PMID: 36241282
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)Epicatechin gallate, 1 mg | sc-204739 | 1 mg | $52.00 | |||
(−)Epicatechin gallate, 5 mg | sc-204739A | 5 mg | $134.00 |