epi-Sancycline (CAS 906364-48-5)

Epi-Sancycline, listed under CAS number 906364-48-5, is a chemically modified derivative of the tetracycline family, specifically designed for advanced scientific research into bacterial protein synthesis and gene regulation mechanisms. Its primary action involves interfering with the translation process in bacterial ribosomes, similar to other tetracyclines, by binding to the 30S subunit. This interaction effectively blocks the attachment of aminoacyl-tRNA to the mRNA-ribosome complex at the acceptor site, which is essential for the elongation of the peptide chain during protein synthesis. This interruption leads to the inhibition of bacterial growth through the prevention of protein production, which is vital for bacterial survival and replication. In research contexts, epi-Sancycline has been utilized to study the specificity and efficacy of ribosomal binding compared to other tetracyclines, offering insights into the structural basis of antibiotic action and resistance. Furthermore, studies employing epi-Sancycline have explored its impact on bacterial transcriptomics and proteomics, providing a deeper understanding of how bacteria respond to ribosomal stress at the molecular level. Such research is instrumental in elucidating the complex interactions between antibiotics and bacterial cells, advancing knowledge in microbial physiology and the development of resistance mechanisms.