EphB3 Antibody (7E5): sc-100299
- EphB3 Antibody (7E5) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 100 µg/ml
- raised against recombinant EphB3 of human origin
- recommended for detection of EphB3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EphB3 Antibody (7E5). This work is in progress.
EphB3 Antibody (7E5) is a mouse monoclonal IgG1 antibody that detects EphB3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). EphB3 is a member of the Eph receptor family, which is the largest group of receptor protein tyrosine kinases identified to date, playing a crucial role in mediating cell-cell interactions during developmental processes and in the central nervous system. EphB3 protein is primarily located on the cell surface, where EphB3 interacts with ephrin ligands, facilitating bidirectional signaling that is essential for neuronal development and synaptic plasticity. Such localization allows EphB3 to participate in the regulation of cell migration, adhesion, and patterning, which are vital for proper neural network formation. Additionally, EphB3 has been implicated in various physiological and pathological processes, including cancer progression and neurodegenerative diseases, making EphB3 a significant target for therapeutic interventions. With an ability to provide insights into the dynamics of cell signaling and development, anti-EphB3 antibody (7E5) serves as an invaluable tool for researchers studying these complex biological systems.
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EphB3 Antibody (7E5) References:
- EphB3 marks delaminating endocrine progenitor cells in the developing pancreas. | Villasenor, A., et al. 2012. Dev Dyn. 241: 1008-19. PMID: 22434763
- Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor. | Bhatia, S., et al. 2018. Mol Cancer Ther. 17: 2049-2059. PMID: 29970482
- Receptor Tyrosine Kinase EphB3: a Prognostic Indicator in Colorectal Carcinoma. | Xuan, Z., et al. 2020. Pathol Oncol Res. 26: 541-549. PMID: 30535864
- Prognostic and Clinicopathological Significance of EphB3 and Dysadherin Expression in Extrahepatic Cholangiocarcinoma. | Wu, Z., et al. 2020. Cancer Manag Res. 12: 221-232. PMID: 32021438
- Expression Profile and Prognostic Significance of EPHB3 in Colorectal Cancer. | Jang, BG., et al. 2020. Biomolecules. 10: PMID: 32294981
- EphB3 as a Potential Mediator of Developmental and Reparative Osteogenesis. | Kamath, RAD. and Benson, MD. 2023. Cells Tissues Organs. 212: 125-137. PMID: 34695818
- Knockdown of EphB3 inhibits cell proliferation partly through the AKT signaling pathway and represses epithelial-mesenchymal transition in esophageal squamous cell carcinoma. | Tang, L., et al. 2022. Transl Cancer Res. 11: 85-98. PMID: 35261887
- Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin. | Huang, H., et al. 2024. Mol Cell Neurosci. 128: 103915. PMID: 38143048
- EphB3 receptor suppressor invasion, migration and proliferation in glioma by inhibiting EGFR-PI3K/AKT signaling pathway. | Xiao, Z., et al. 2024. Brain Res. 1830: 148796. PMID: 38341169
- The lack of EphB3 receptor prevents bone loss in mouse models of osteoporosis. | Rodríguez-Sosa, MR., et al. 2024. J Bone Miner Res. 39: 1008-1024. PMID: 38739682
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EphB3 Antibody (7E5) | sc-100299 | 100 µg/ml | $339.00 |