EPCR Antibody (LMR-42): sc-57106
- EPCR Antibody (LMR-42) is a rat monoclonal IgG2a provided at 500 µl supernatant
- raised against doxorubicin resistant non small lung cancer SW 1573/2R120 cells of human origin
- recommended for detection of EPCR of mouse, rat and human origin by IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EPCR Antibody (LMR-42). This work is in progress.
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EPCR Antibody (LMR-42) is a rat monoclonal IgG2a antibody that detects EPCR in mouse, rat, and human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Anti-EPCR antibody (LMR-42) is available in a non-conjugated form, allowing for versatile experimental setups. The endothelial Protein C receptor (EPCR) plays a crucial role in the regulation of coagulation and inflammation by facilitating the activation of Protein C, which is essential for maintaining hemostatic balance. Located predominantly on the surface of endothelial cells in large blood vessels, particularly in the heart and lungs, EPCR enhances the anticoagulant pathway initiated by the TM/Thrombin complex. This complex is vital for converting Protein C into its activated form, which subsequently inactivates key clotting factors, thereby preventing excessive thrombin formation and promoting vascular health. EPCR expression is not only significant for anticoagulant properties but also for involvement in inflammatory responses, as EPCR can modulate the interaction between coagulation and inflammation. Additionally, the EPCR gene is located on human chromosome 20q11.2, and EPCR protein structure reveals homology to the major histocompatibility complex, indicating evolutionary importance and potential implications in immune responses. Understanding EPCR function and location is essential for developing therapeutic strategies targeting coagulation disorders and inflammatory diseases.
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EPCR Antibody (LMR-42) References:
- The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. | Ye, X., et al. 1999. Biochem Biophys Res Commun. 259: 671-7. PMID: 10364477
- Organization and chromosomal localization of the human endothelial protein C receptor gene. | Hayashi, T., et al. 1999. Gene. 238: 367-73. PMID: 10570964
- Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. | Liaw, PC., et al. 2000. J Biol Chem. 275: 5447-52. PMID: 10681521
- The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness. | Esmon, CT. 2001. Crit Care. 5: S7-12. PMID: 11379986
- Gene targeting in hemostasis: protein C. | Castellino, FJ. 2001. Front Biosci. 6: D807-19. PMID: 11438441
- The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. | Gleeson, EM., et al. 2012. Cell Mol Life Sci. 69: 717-26. PMID: 21968919
- Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. | Fukudome, K. and Esmon, CT. 1995. J Biol Chem. 270: 5571-7. PMID: 7890676
- Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. | Fukudome, K., et al. 1998. J Exp Med. 187: 1029-35. PMID: 9529319
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EPCR Antibody (LMR-42) | sc-57106 | 500 µl supernatant | $322.00 |