eotaxin-3 Antibody (500-M32): sc-65349

eotaxin-3 Antibody (500-M32) is a mouse monoclonal IgG1 antibody that detects eotaxin-3 in human samples through enzyme-linked immunosorbent assay (ELISA). Eotaxin-3, a member of the C-C chemokine family, plays a crucial role in the immune response by mediating the migration of eosinophils and basophils to sites of inflammation, which is vital for combating parasitic infections and modulating allergic responses. This chemokine is primarily produced by various cell types, including epithelial cells and fibroblasts, and eotaxin-3 expression is significantly upregulated in response to inflammatory stimuli. Eotaxin-3 interacts with the CCR3 receptor, which is predominantly expressed on eosinophils, thereby facilitating their recruitment to tissues where they can exert their effects. Notably, eotaxin-3 exhibits a higher potency in inducing eosinophil migration compared to eotaxin-2, requiring a tenfold lower concentration to achieve similar effects. The gene encoding eotaxin-3 is located on human chromosome 7q11.23, and understanding eotaxin-3 function and interactions is essential for developing therapeutic strategies targeting allergic diseases and asthma. Anti-eotaxin-3 antibody (500-M32) is an invaluable tool for researchers investigating the role of this chemokine in various biological processes and disease states.