EOC 20 Whole Cell Lysate: sc-364187

EOC 20 whole cell lysate is derived from the EOC 20 cell line, which originates from murine ovarian surface epithelial cells, offering a robust model for studying ovarian cell biology and carcinogenesis in a research setting. This lysate is particularly useful for exploring the molecular mechanisms of ovarian epithelial cell transformation and the early stages of ovarian tumorigenesis. Researchers utilize EOC 20 lysate to study changes in gene expression, protein-protein interactions, and signaling pathways that are relevant to the development of ovarian cancer. A key focus of study involves the PI3K/Akt and MAPK pathways, which are crucial for cell proliferation and survival, often deregulated in ovarian cancer cells. The lysate also helps in understanding the role of tumor suppressors and oncogenes in ovarian cells, providing insights into the cellular processes that drive malignant transformation. By using this lysate, scientists can dissect the cellular responses to environmental and genetic modifications, enhancing our understanding of the pathophysiological conditions leading to ovarian cancer.

EOC 20 Whole Cell Lysate References:

1. Neuregulin upregulates microglial α7 nicotinic acetylcholine receptor expression in immortalized cell lines: implications for regulating neuroinflammation.  |  Mencel, M., et al. 2013. PLoS One. 8: e70338. PMID: 23936190
2. Widespread Expression of Erythropoietin Receptor in Brain and Its Induction by Injury.  |  Ott, C., et al. 2015. Mol Med. 21: 803-815. PMID: 26349059