Entecavir Labeled d2, 15N, 13C (CAS 142217-69-4 (unlabeled))

Entecavir Labeled d2, 15N, 13C is a triple-labeled isotopic variant of entecavir, where specific atoms in the molecule have been replaced with isotopes—deuterium (d2), nitrogen-15 (15N), and carbon-13 (13C). This isotopic labeling enhances the compound′s utility in scientific research, particularly in studies involving sophisticated analytical techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Entecavir is a nucleoside analog that primarily inhibits the viral DNA polymerase of hepatitis B virus (HBV), impeding its ability to reverse transcribe viral RNA into DNA, a critical step in the viral replication cycle. The labeled version, Entecavir Labeled d2, 15N, 13C, retains this mechanism of action but offers additional benefits for research by providing a means to track and analyze the molecule′s interaction and metabolism within biological systems with greater precision. In research, the isotopic labels in Entecavir Labeled d2, 15N, 13C allow for more accurate quantification and detection of the molecule and its metabolites in biological samples. This is particularly useful in studies to understand how the molecule is absorbed, distributed, metabolized, and excreted. The heavier isotopes provide distinct spectral signatures that reduce background noise and increase measurement sensitivity and resolution. Additionally, the labeled entecavir is used in metabolic studies to investigate the molecule′s biochemical pathways and interactions at the cellular level. Scientists can use this information to study how modifications to the molecule′s structure impact its efficacy and stability, and how it interacts with other molecules within the cell.