Date published: 2026-5-13

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Entacapone (CAS 130929-57-6)

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Alternate Names:
(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
Application:
Entacapone is a peripherally acting inhibitor of catechol-O-methyl transferase
CAS Number:
130929-57-6
Purity:
≥99%
Molecular Weight:
305.29
Molecular Formula:
C14H15N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Entacapone is a compound extensively utilized in research focused on the inhibition of catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines. In biochemical studies, Entacapone helps to understand the mechanism of COMT and its role in the catabolism of neurotransmitters such as dopamine. It serves as a useful tool in the investigation of the metabolic pathways that influence the duration and effect of certain neurotransmitters in the brain. Additionally, Entacapone is integral to studies examining how the modulation of COMT activity affects the concentration of biologically active catechols in various tissues. In neuroscientific research, it facilitates the exploration of dopaminergic signaling and its implications for motor control and behavior.


Entacapone (CAS 130929-57-6) References

  1. Entacapone. A review of its use in Parkinson's disease.  |  Holm, KJ. and Spencer, CM. 1999. Drugs. 58: 159-77. PMID: 10439935
  2. The role of entacapone in the management of Parkinson's disease.  |  Brooks, DJ., et al. 2000. Hosp Med. 61: 267-71. PMID: 10858804
  3. Entacapone.  |  Chong, BS. and Mersfelder, TL. 2000. Ann Pharmacother. 34: 1056-65. PMID: 10981253
  4. Entacapone: a catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson's disease.  |  Najib, J. 2001. Clin Ther. 23: 802-32; discussion 771. PMID: 11440283
  5. Entacapone/levodopa/carbidopa combination tablet: Stalevo.  |  . 2003. Drugs R D. 4: 310-1. PMID: 12952501
  6. Clinical advantages of COMT inhibition with entacapone - a review.  |  Gordin, A., et al. 2004. J Neural Transm (Vienna). 111: 1343-63. PMID: 15340869
  7. Entacapone in the treatment of Parkinson's disease.  |  Schrag, A. 2005. Lancet Neurol. 4: 366-70. PMID: 15907741
  8. Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease.  |  Lees, AJ. 2008. CNS Neurosci Ther. 14: 83-93. PMID: 18482101
  9. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.  |  Peng, S., et al. 2019. Sci Transl Med. 11: PMID: 30996080
  10. Entacapone Treatment Modulates Hippocampal Proteins Related to Synaptic Vehicle Trafficking.  |  Yoo, DY., et al. 2020. Cells. 9: PMID: 33352833
  11. Fast Detection of Entacapone by a Lanthanide-Organic Framework with Rhombic Channels.  |  Min, H., et al. 2021. Chemistry. 27: 17459-17464. PMID: 34608690
  12. Clinical Pharmacology of Entacapone (Comtan) From the FDA Reviewer.  |  Habet, S. 2022. Int J Neuropsychopharmacol. 25: 567-575. PMID: 35302623
  13. Entacapone alleviates acute kidney injury by inhibiting ferroptosis.  |  Yang, J., et al. 2022. FASEB J. 36: e22399. PMID: 35691001
  14. [Triple combination of levodopa, carbidopa and entacapone by intrajejunal pump in advanced Parkinson's disease].  |  Györfi, B., et al. 2022. Ideggyogy Sz. 75: 365-368. PMID: 36541150

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Entacapone, 10 mg

sc-218315
10 mg
$125.00