ENT4 Antibody (SA-18): sc-101295

ENT4 Antibody (SA-18) is a mouse monoclonal IgG2a kappa light chain antibody that detects ENT4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ENT4 antibody (SA-18) is available as a non-conjugated format. ENT4 protein, also known as SLC29A4 (solute carrier family 29 member 4) or PMAT, is a crucial 530 amino acid plasma membrane protein that plays a significant role in the transport of various nucleosides and monoamines, including dopamine and serotonin, across cell membranes. This transport is vital for maintaining proper neural signaling and neurotransmitter balance, particularly in the brain, where ENT4 is highly expressed. ENT4′s location in the plasma membrane is essential as this protein facilitates the uptake of these neurotransmitters into presynaptic neurons, thereby influencing synaptic transmission and overall neuronal communication. ENT4′s activity is not reliant on intracellular ion concentrations, such as calcium and sodium, but is sensitive to changes in membrane potential, highlighting ENT4′s role in dynamic cellular environments. Multiple isoforms of ENT4, resulting from alternative splicing, further underscore the complexity of ENT4′s function and regulation in different tissues.

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ENT4 Antibody (SA-18) References:

1. The equilibrative nucleoside transporter family, SLC29.  |  Baldwin, SA., et al. 2004. Pflugers Arch. 447: 735-43. PMID: 12838422
2. Identification and characterization of a novel monoamine transporter in the human brain.  |  Engel, K., et al. 2004. J Biol Chem. 279: 50042-9. PMID: 15448143
3. Interaction of organic cations with a newly identified plasma membrane monoamine transporter.  |  Engel, K. and Wang, J. 2005. Mol Pharmacol. 68: 1397-407. PMID: 16099839
4. Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.  |  Barnes, K., et al. 2006. Circ Res. 99: 510-9. PMID: 16873718
5. Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells.  |  Xia, L., et al. 2007. Am J Physiol Renal Physiol. 292: F682-90. PMID: 17018840
6. Molecular determinants of substrate selectivity of a novel organic cation transporter (PMAT) in the SLC29 family.  |  Zhou, M., et al. 2007. J Biol Chem. 282: 3188-95. PMID: 17121826
7. The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.  |  Bottalico, B., et al. 2007. Mol Reprod Dev. 74: 1303-11. PMID: 17393420
8. Cellular localization and functional characterization of the equilibrative nucleoside transporters of antitumor nucleosides.  |  Endo, Y., et al. 2007. Cancer Sci. 98: 1633-7. PMID: 17711502

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ENT4 Antibody (SA-18) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ENT4 Antibody (SA-18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ENT4 Antibody (SA-18) Specifications

Alternate Product Name: ENT4

Product Clone Name: SA-18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 283-346

Epitope Target: ENT4

Epitope Species: human

Product Reactivity/Detection: ENT4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ENT4 Antibody (SA-18): N/A