ENT1 Antibody (G-6): sc-515240

ENT1 Antibody (G-6) is a mouse monoclonal IgM antibody that detects equilibrative nucleoside transporter 1 (ENT1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ENT1 plays a crucial role in the transport of nucleosides across cell membranes, facilitating the uptake of essential molecules like adenosine, which is vital for various physiological processes including neurotransmission and cellular signaling. Anti-ENT1 antibody (G-6) is particularly important in studying drug delivery, as ENT1 is responsible for the uptake of antiviral and anticancer nucleoside drugs, thereby influencing therapeutic efficacy. Located primarily in the plasma membrane, ENT1 is part of the solute carrier family 29 and works in concert with other transporters, such as ENT3, to regulate nucleoside levels within the cell. This regulation is essential for maintaining cellular homeostasis and ensuring that cells can respond appropriately to external signals. ENT1 (G-6) antibody is an invaluable tool for researchers studying nucleoside transport mechanisms and their implications in health and disease.

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ENT1 Antibody (G-6) References:

1. Biodistribution and uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor model.  |  Paproski, RJ., et al. 2010. J Nucl Med. 51: 1447-55. PMID: 20720035
2. Human erythrocyte nucleoside transporter ENT1 functions at ice-cold temperatures.  |  Takano, M., et al. 2010. Drug Metab Pharmacokinet. 25: 351-60. PMID: 20814156
3. The Equilibrative Nucleoside Transporter (ENT1) can be phosphorylated at multiple sites by PKC and PKA.  |  Reyes, G., et al. 2011. Mol Membr Biol. 28: 412-26. PMID: 21809900
4. The adenosine transporter, ENT1, in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner: implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity.  |  Ramadan, A., et al. 2014. Purinergic Signal. 10: 305-12. PMID: 24163005
5. Contribution of CNT1 and ENT1 to ribavirin uptake in human hepatocytes.  |  Choi, MK., et al. 2015. Arch Pharm Res. 38: 904-13. PMID: 25011570
6. Paraspinal Muscle Contractile Function is Impaired in the ENT1-deficient Mouse Model of Progressive Spine Pathology.  |  Noonan, AM., et al. 2021. Spine (Phila Pa 1976). 46: E710-E718. PMID: 33332787
7. Ectopic mineralisation of the mandibular symphysis in ENT1 knockout mice: A model of dystrophic calcification.  |  Fournier, DE., et al. 2021. Bone Rep. 15: 101100. PMID: 34258331
8. Dopamine Release in Nucleus Accumbens Is under Tonic Inhibition by Adenosine A1 Receptors Regulated by Astrocytic ENT1 and Dysregulated by Ethanol.  |  Roberts, BM., et al. 2022. J Neurosci. 42: 1738-1751. PMID: 35042768
9. PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID-19 patients.  |  Hau, RK., et al. 2022. Clin Transl Sci. 15: 1599-1605. PMID: 35505633
10. Pharmacological inhibition of ENT1 enhances the impact of specific dietary fats on energy metabolism gene expression.  |  Pain, E., et al. 2024. Proc Natl Acad Sci U S A. 121: e2321874121. PMID: 39207736

The preferred ENT1 antibody is ENT1 Antibody (F-12): sc-377283.