ent S-(+)-Atomoxetine Hydrochloride (CAS 82857-39-4)
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ent S-(+)-Atomoxetine Hydrochloride is an enantiomer of Atomoxetine (Tomoxetine, LY 139603; sc-204349). This enantiomer is reported to be less effective than Tomoxetine as a competitive and specific inhibitor of norepinephrine reuptake. Tomoxetine (Atomoxetine, LY 139603; sc-204349) is a competitve and specific inhibitor of norepinephrine reuptake while demonstrating weak serotonin and dopamine inhibition as studied in synaptosomes of rat hypothalamus. Additional studies indicate that this (-) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride; sc-211408). Additionally, in the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain.
ent S-(+)-Atomoxetine Hydrochloride (CAS 82857-39-4) References
- Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. | Bymaster, FP., et al. 2002. Neuropsychopharmacology. 27: 699-711. PMID: 12431845
- Catecholamine influences on dorsolateral prefrontal cortical networks. | Arnsten, AF. 2011. Biol Psychiatry. 69: e89-99. PMID: 21489408
- A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. | Wong, DT., et al. 1982. J Pharmacol Exp Ther. 222: 61-5. PMID: 6123593
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ent S-(+)-Atomoxetine Hydrochloride, 5 mg | sc-211408 | 5 mg | $380.00 |