ent-Prostaglandin E2 (CAS 65085-69-0)
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Ent-Prostaglandin E2 is the enantiomer of enzymatically-derived prostaglandin E2 (PGE2; sc-201225). Both are optically pure compounds whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Significant amounts of racemic PGE2 are created in vitro in settings of oxidative stress via isoprostane pathway intermediates. Inhibition of COX-2 with Aspirin (sc-202471) reportedly reduces thromboxane A2 synthesis by 90% and PGI2 by > 80%, however, the same concentration decreases PGE2 by only 60%; this may be at least partially explained by free radical-catalyzed formation of stereoisomers of PGE2. Ent-Prostaglandin E2 could potentially be used as an analytical standard in the deconvolution of these extremely relevant, but complex biochemical issues.
ent-Prostaglandin E2 (CAS 65085-69-0) References
- Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. | Gao, L., et al. 2003. J Biol Chem. 278: 28479-89. PMID: 12746435
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ent-Prostaglandin E2, 1 mg | sc-205311 | 1 mg | $68.00 | |||
ent-Prostaglandin E2, 5 mg | sc-205311A | 5 mg | $309.00 |