Molecular structure of ent Atomoxetine-d3, Hydrochloride
ent Atomoxetine-d3, Hydrochloride
Application:
ent Atomoxetine-d3, Hydrochloride is a labeled enantiomer of Tomoxetine
Molecular Weight:
294.83
Molecular Formula:
C17H19D3ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ent Atomoxetine-d3, Hydrochloride is a labeled enantioner of Tomoxetine. Tomoxetine (Atomoxetine, LY 139603; sc-204349) is a competitve and specific inhibitor of norepinephrine reuptake while demonstrating weak serotonin and dopamine inhibition as studied in synaptosomes of rat hypothalamus. Additional studies indicate that this (−) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride; sc-211408). Additionally, in the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain.
ent Atomoxetine-d3, Hydrochloride References
- Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. | Bymaster, FP., et al. 2002. Neuropsychopharmacology. 27: 699-711. PMID: 12431845
- Catecholamine influences on dorsolateral prefrontal cortical networks. | Arnsten, AF. 2011. Biol Psychiatry. 69: e89-99. PMID: 21489408
- A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. | Wong, DT., et al. 1982. J Pharmacol Exp Ther. 222: 61-5. PMID: 6123593
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ent Atomoxetine-d3, Hydrochloride, 1 mg | sc-218309 | 1 mg | $300.00 |