ENMD 547 (CAS 644961-61-5)
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ENMD 547 functions as a selective antagonist for Protease-Activated Receptor 2 (PAR-2), demonstrating its efficacy through a dose-dependent inhibition of calcium signaling pathways in Lewis lung carcinoma cells. This specificity is highlighted by its targeted inhibition when cells are stimulated with either a soluble peptide PAR-2 agonist or trypsin, an enzyme that can activate PAR-2 by proteolytic cleavage. Interestingly, ENMD 547 exhibits no inhibitory effect on calcium signaling when cells are stimulated with a soluble PAR-1 agonist, underscoring its selectivity for PAR-2. This characteristic makes ENMD 547 useful in research focused on dissecting the roles of protease-activated receptors, particularly PAR-2, in cellular signaling processes.
ENMD 547 (CAS 644961-61-5) References
- PAR2 Inhibition Enhanced the Sensitivity of Colorectal Cancer Cells to 5-FU and Reduced EMT Signaling. | Quan, Q., et al. 2019. Oncol Res. 27: 779-788. PMID: 30841957
- Inhibition of protein disulfide isomerase with PACMA-31 regulates monocyte tissue factor through transcriptional and posttranscriptional mechanisms. | Beckmann, L., et al. 2022. Thromb Res. 220: 48-59. PMID: 36265413
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ENMD 547, 20 mg | sc-207618 | 20 mg | $306.00 |