Endothelial Lipase Antibody (4A9): sc-517036
- Endothelial Lipase Antibody (4A9) is a mouse monoclonal IgG2a κ Endothelial Lipase antibody provided at 100 µg/ml
- raised against amino acids 21-500 representing full length Endothelial Lipase of human origin
- recommended for detection of Endothelial Lipase of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Endothelial Lipase Antibody (4A9). This work is in progress.
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Endothelial Lipase Antibody (4A9) is a mouse monoclonal IgG2a kappa light chain antibody that detects human Endothelial Lipase protein by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Endothelial Lipase antibody (4A9) is available as a non-conjugated format. Endothelial lipase, also known as endothelial cell-derived lipase, belongs to the lipase gene family, one of the largest genetic superfamilies in living organisms, including esterases and thioesterases. Endothelial lipase functions critically in lipid metabolism, demonstrating both triglyceride and phospholipase activity for hydrolyzing triglycerides and phospholipids in lipoproteins. Endothelial lipase is mainly produced in endothelial cells and appears in various tissues, including placenta, liver, thyroid, kidney, lung, testis, and ovary. Heparin-binding properties of Endothelial lipase enhance lipoprotein interactions, supporting lipid metabolism and cardiovascular health. Mutations in lipase family members, such as lipoprotein lipase, can cause severe metabolic disorders, emphasizing Endothelial lipase′s crucial role in lipid homeostasis.
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Endothelial Lipase Antibody (4A9) References:
- A novel endothelial-derived lipase that modulates HDL metabolism. | Jaye, M., et al. 1999. Nat Genet. 21: 424-8. PMID: 10192396
- Characterization of the lipolytic activity of endothelial lipase. | McCoy, MG., et al. 2002. J Lipid Res. 43: 921-9. PMID: 12032167
- Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation. | Kojma, Y., et al. 2004. J Biol Chem. 279: 54032-8. PMID: 15485805
- Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. | Kratky, D., et al. 2005. J Clin Invest. 115: 161-7. PMID: 15630456
- Endothelial lipase is inactivated upon cleavage by the members of the proprotein convertase family. | Gauster, M., et al. 2005. J Lipid Res. 46: 977-87. PMID: 15722560
- Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine. | Gauster, M., et al. 2005. J Lipid Res. 46: 1517-25. PMID: 15834125
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. | Liu, T., et al. 2005. J Proteome Res. 4: 2070-80. PMID: 16335952
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Endothelial Lipase Antibody (4A9) | sc-517036 | 100 µg/ml | $322.00 |