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Enclomiphene hydrochloride (CAS 14158-65-7)

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Alternate Names:
(E)-2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-triethylamine Hydrochloride
CAS Number:
14158-65-7
Molecular Weight:
442.42
Molecular Formula:
C26H29Cl2NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Enclomiphene hydrochloride, a synthetic compound originating from the natural hormone clomiphene citrate, finds application in laboratory experiments aimed at investigating hormonal impacts on the body. Functioning as a potent estrogen receptor agonist, this compound effectively stimulates receptor activity. Consequently, the initiated receptor activity sets in motion a series of interconnected processes within the body, culminating in the synthesis of hormones and various bioactive compounds. Thus, enclomiphene hydrochloride serves as useful for delving into the intricate effects of estrogen on physiological mechanisms.


Enclomiphene hydrochloride (CAS 14158-65-7) References

  1. Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women.  |  Young, SL., et al. 1999. Fertil Steril. 71: 639-44. PMID: 10202872
  2. Enclomiphene does not alter the postpartum interval of suckled beef cows.  |  Schramm, RD., et al. 1991. J Anim Sci. 69: 4112-6. PMID: 1778825
  3. Tamoxifen-stimulated growth of human endometrial carcinoma.  |  Jordan, VC., et al. 1991. Ann N Y Acad Sci. 622: 439-46. PMID: 1905895
  4. Clomiphene citrate and enclomiphene for the treatment of hypogonadal androgen deficiency.  |  Kaminetsky, J. and Hemani, ML. 2009. Expert Opin Investig Drugs. 18: 1947-55. PMID: 19938905
  5. Effects of enclomiphene on estradiol-induced changes in LH secretion in ewes.  |  Gregg, DW. and Nett, TM. 1990. J Anim Sci. 68: 3293-9. PMID: 2123847
  6. Enclomiphene induces luteolysis in the nonpregnant guinea pig.  |  Westfahl, PK. 1989. Experientia. 45: 104-6. PMID: 2492231
  7. Postpartum interval in beef cows shortened by enclomiphene.  |  Chang, CF. and Reeves, JJ. 1987. J Anim Sci. 65: 217-23. PMID: 3112086
  8. Differential responses of sex steroid target tissues of rats treated with 4-hydroxyandrostenedione.  |  Wing, LY., et al. 1988. Endocrinology. 122: 2418-27. PMID: 3131115
  9. Rabbit liver microsomal metabolism of enclomiphene.  |  Ruenitz, PC. 1981. Drug Metab Dispos. 9: 456-60. PMID: 6117445
  10. Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture.  |  Huang, ES. and Miller, WL. 1983. Endocrinology. 112: 442-8. PMID: 6401242
  11. Inhibition of the estradiol-induced growth of cultured human breast cancer cells by the anti-estrogens tamoxifen, desmethyl-tamoxifen, 4-hydroxy-tamoxifen and enclomiphene.  |  Marth, C., et al. 1984. Biochem Pharmacol. 33: 3951-6. PMID: 6439216
  12. Geometric isomers of substituted triphenylethylenes and antiestrogen action.  |  Jordan, VC., et al. 1981. Endocrinology. 108: 1353-61. PMID: 6781873
  13. The inhibition of the estrogen receptor's positive cooperative [3H]estradiol binding by the antagonist, clomiphene.  |  Sasson, S. and Notides, AC. 1982. J Biol Chem. 257: 11540-5. PMID: 7118895
  14. Effects of enclomiphene and zuclomiphene on basal and gonadotrophin-stimulated progesterone secretion by isolated subpopulations of small and large ovine luteal cells.  |  Opsahl, MS., et al. 1996. Hum Reprod. 11: 1250-5. PMID: 8671435
  15. Differential responses of estrogen target tissues in rats including bone to clomiphene, enclomiphene, and zuclomiphene.  |  Turner, RT., et al. 1998. Endocrinology. 139: 3712-20. PMID: 9724022

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Enclomiphene hydrochloride, 5 mg

sc-478069
5 mg
$177.00