Molecular structure of Enalaprilat, CAS Number: 76420-72-9
Enalaprilat (CAS 76420-72-9)
See product citations (3)
Alternate Names:
Enalaprilic acid; Enalaprilatum
Application:
Enalaprilat is an active metabolite of Enalapril
CAS Number:
76420-72-9
Purity:
≥99%
Molecular Weight:
348.39
Molecular Formula:
C18H24N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Enalaprilat is the active form of Enalapril (sc-205664). Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-beta, IL-6, and NF-kappaB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.
Enalaprilat (CAS 76420-72-9) References
- The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets. | Lupi, R., et al. 2006. Eur J Endocrinol. 154: 355-61. PMID: 16452552
- Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. | Loftsson, T., et al. 2010. Acta Ophthalmol. 88: 337-41. PMID: 19432862
- Spironolactone and enalapril differentially up-regulate the expression of VEGF and heme oxygenase-1 in the neonatal rat kidney. | Yim, HE., et al. 2011. Pediatr Res. 69: 378-83. PMID: 21263376
- [Effects of enalapril on NF-kappaB expression in mucus hypersecretion rats induced by acrolein exposure]. | Zhang, YH., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 998-1002. PMID: 21265102
- [Effects of enalapril on IL-1beta, IL-6 expression in rat lung exposure to acrolein]. | Wang, SL., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 1003-7, 1038. PMID: 21265103
- Clinical pharmacokinetics of the newer ACE inhibitors. A review. | Kelly, JG. and O'Malley, K. 1990. Clin Pharmacokinet. 19: 177-96. PMID: 2203579
- The effect of candesartan on the pharmacokinetics of enalaprilat in nephrotic rats. | Bi, BT., et al. 2012. Eur Rev Med Pharmacol Sci. 16: 2162-70. PMID: 23280035
- Intracoronary EnalaPrilat to Reduce MICROvascular Damage During Percutaneous Coronary Intervention (ProMicro) study. | Mangiacapra, F., et al. 2013. J Am Coll Cardiol. 61: 615-21. PMID: 23290547
- Enalaprilat increases PPARβ/Δ expression, without influence on PPARα and PPARγ, and modulate cardiac function in sub-acute model of daunorubicin-induced cardiomyopathy. | Cernecka, H., et al. 2013. Eur J Pharmacol. 714: 472-7. PMID: 23834779
- [Increase in lipophilicity of enalaprilat by complexation with copper(II) or zinc(II) Ions]. | Fujioka, H., et al. 2013. Yakugaku Zasshi. 133: 1135-41. PMID: 23903258
- Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat. | Ferslew, BC., et al. 2014. Drug Metab Dispos. 42: 1567-74. PMID: 24958844
- Pharmacokinetics and pharmacodynamics of enalapril and its active metabolite, enalaprilat, at four different doses in healthy horses. | Gómez-Díez, M., et al. 2014. Res Vet Sci. 97: 105-10. PMID: 24972864
- Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat. | Matus, M., et al. 2015. Mol Cell Biochem. 403: 199-208. PMID: 25663023
Inhibitor of:
ACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Enalaprilat, 50 mg | sc-205669 | 50 mg | $200.00 | |||
Enalaprilat, 250 mg | sc-205669A | 250 mg | $600.00 |