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Enalapril (CAS 75847-73-3)

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Alternate Names:
N-[(2S)-1-Ethoxy-1-oxo-4-phenyl-2-butanyl]-L-alanyl-L-proline
Application:
Enalapril is an angiotensin-converting enzyme inhibitor
CAS Number:
75847-73-3
Purity:
≥98%
Molecular Weight:
376.45
Molecular Formula:
C20H28N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Enalapril is a compound extensively studied in the context of cardiovascular research due to its action as an angiotensin-converting enzyme (ACE) inhibitor. This activity is of particular interest in understanding the regulation of blood pressure and the renin-angiotensin system, a hormonal system that plays a key role in maintaining fluid and electrolyte balance, as well as systemic vascular resistance. Enalapril is used to investigate the effects of ACE inhibition on hypertension and to explore the mechanisms underlying cardiac remodeling post-myocardial infarction. Enalapril serves as a model compound in studies that aim to comprehend the absorption, distribution, and elimination of ACE inhibitors, which can influence the design and optimization of new compounds with similar mechanisms of action. Through these research applications, enalapril contributes to the broader understanding of cardiovascular physiology and the complex interactions of the renin-angiotensin system.


Enalapril (CAS 75847-73-3) References

  1. Hemodynamic comparisons of enalapril and felodipine and their combination.  |  Morgan, TO. and Anderson, A. 1992. Kidney Int Suppl. 36: S78-81. PMID: 1614072
  2. The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.  |  Lupi, R., et al. 2006. Eur J Endocrinol. 154: 355-61. PMID: 16452552
  3. Spironolactone and enalapril differentially up-regulate the expression of VEGF and heme oxygenase-1 in the neonatal rat kidney.  |  Yim, HE., et al. 2011. Pediatr Res. 69: 378-83. PMID: 21263376
  4. [Effects of enalapril on NF-kappaB expression in mucus hypersecretion rats induced by acrolein exposure].  |  Zhang, YH., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 998-1002. PMID: 21265102
  5. [Effects of enalapril on IL-1beta, IL-6 expression in rat lung exposure to acrolein].  |  Wang, SL., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 1003-7, 1038. PMID: 21265103
  6. Rapid and sensitive liquid chromatography/tandem mass spectrometry method for simultaneous determination of enalapril and its major metabolite enalaprilat, in human plasma: application to a bioequivalence study.  |  Ghosh, C., et al. 2012. Drug Test Anal. 4: 94-103. PMID: 21341376
  7. Clinical pharmacokinetics of the newer ACE inhibitors. A review.  |  Kelly, JG. and O'Malley, K. 1990. Clin Pharmacokinet. 19: 177-96. PMID: 2203579
  8. Greener bioanalytical approach for LC/MS-MS assay of enalapril and enalaprilat in human plasma with total replacement of acetonitrile throughout all analytical stages.  |  Cheregi, M., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 927: 124-32. PMID: 23266124
  9. [Examinations on the pharmacokinetics and compatibility of enalapril in racing pigeons].  |  Pees, M., et al. 2013. Tierarztl Prax Ausg K Kleintiere Heimtiere. 41: 319-25. PMID: 24127029
  10. Decreased sympathetic tone after short-term treatment with enalapril in dogs with mild chronic mitral valve disease.  |  Chompoosan, C., et al. 2014. Res Vet Sci. 96: 347-54. PMID: 24559801
  11. Simultaneous quantitative and qualitative analysis of aliskiren, enalapril and its active metabolite enalaprilat in undiluted human urine utilizing LC-ESI-MS/MS.  |  Burckhardt, BB., et al. 2014. Biomed Chromatogr. 28: 1679-91. PMID: 24788577
  12. Pharmacokinetics and pharmacodynamics of enalapril and its active metabolite, enalaprilat, at four different doses in healthy horses.  |  Gómez-Díez, M., et al. 2014. Res Vet Sci. 97: 105-10. PMID: 24972864
  13. Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.  |  Tarkiainen, EK., et al. 2015. Br J Clin Pharmacol. 80: 1131-8. PMID: 25919042
  14. Study of Copolymer Composition on Drug Loading Efficiency of Enalapril in Polymersomes and Cytotoxicity of Drug Loaded Nanoparticles.  |  Danafar, H., et al. 2016. Drug Res (Stuttg). 66: 495-504. PMID: 27434113

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Enalapril, 100 mg

sc-205664
100 mg
$159.00

Enalapril, 1 g

sc-205664B
1 g
$669.00

Enalapril, 5 g

sc-205664A
5 g
$2556.00

Please, provide information about photo stability of Enalapril. Regards, Ivo

Asked by: Ivos
sc-205664 is stable when exposed to natural light and normal lighting within a lab setting. It is recommended to store sc-205664 in a cool dark place, preferably in the refrigerator.
Answered by: Technical Support
Date published: 2019-02-26
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Rated 5 out of 5 by from Excelente resultadocomodo almacenaje, se disuelve muy bien. Me gusta mas que otras marcas
Date published: 2024-02-20
Rated 5 out of 5 by from Yim et alYim et al. (PubMed ID 21263376) found that Enalapril increased VEGF and HO-1 protein expression via aldosterone or angiotensin II inhibition in rat kiney cells. -SCBT Publication Review
Date published: 2015-05-07
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Enalapril is rated 5.0 out of 5 by 2.
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