Molecular structure of Emodin, CAS Number: 518-82-1
Emodin (CAS 518-82-1)
See product citations (2)
Alternate Names:
1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione
Application:
Emodin is a potent Lck tyrosine kinase inhibitor shown to suppress Neu tyrosine kinase activity
CAS Number:
518-82-1
Purity:
≥95%
Molecular Weight:
270.24
Molecular Formula:
C15H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Emodin is a potent Lck (p56lck tyrosine kinase) inhibitor (IC50 = 18.5 muM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 muM). Emodin may act to suppress HER2/Neu tyrosine kinase activity in HER2/Neu overexpressing breast cancer cells. Emodin is an inhibitor of casein kinase.
Emodin (CAS 518-82-1) References
- Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. | Jayasuriya, H., et al. 1992. J Nat Prod. 55: 696-8. PMID: 1517743
- Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. | Pickhardt, M., et al. 2005. J Biol Chem. 280: 3628-35. PMID: 15525637
- Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway. | Shen, C., et al. 2021. J Ethnopharmacol. 279: 114340. PMID: 34171397
- Emodin Alleviates Intestinal Barrier Dysfunction by Inhibiting Apoptosis and Regulating the Immune Response in Severe Acute Pancreatitis. | Zhou, Q., et al. 2021. Pancreas. 50: 1202-1211. PMID: 34714285
- Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa. | Zhang, FY., et al. 2022. Phytomedicine. 95: 153786. PMID: 34785104
- Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo. | Liu, Y., et al. 2022. Inflammation. 45: 753-767. PMID: 34787801
- Emodin Promotes Autophagy and Prevents Apoptosis in Sepsis-Associated Encephalopathy through Activating BDNF/TrkB Signaling. | Gao, LL., et al. 2022. Pathobiology. 89: 135-145. PMID: 34872094
- Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway. | Luo, M., et al. 2022. Ann Anat. 240: 151885. PMID: 34958913
- Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer. | Sougiannis, AT., et al. 2022. Am J Physiol Gastrointest Liver Physiol. 322: G383-G395. PMID: 35018819
- Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin. | Qin, B., et al. 2022. BMC Cancer. 22: 671. PMID: 35715752
- Emodin modulates gut microbial community and triggers intestinal immunity. | Mabwi, HA., et al. 2023. J Sci Food Agric. 103: 1273-1282. PMID: 36088620
- Emodin coupled with high LET neutron beam-a novel approach to treat on glioblastoma. | Kim, JY., et al. 2022. J Radiat Res. 63: 817-827. PMID: 36253116
- Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. | Chen, C., et al. 2022. Eur J Pharmacol. 936: 175329. PMID: 36341884
- Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. | Chan, TC., et al. 1993. Biochem Biophys Res Commun. 193: 1152-8. PMID: 7686746
- Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin. | Zhang, L. and Hung, MC. 1996. Oncogene. 12: 571-6. PMID: 8637714
Inhibitor of:
β-Glucoronidase, 4930444G20Rik, 9430070O13Rik, ADCK4, ALDH1A1, ATAD4, ATF-3, BPV E2, C6ST-1, Casein Kinase, Casein Kinase II, casein kinase II alpha, casein kinase IIβ, CCDC100, CCDC139, CD32-A_Fc γ RIII, COL18A1, COL6A, Coronavirus nucleocapsid, CSNK1A1L, CXorf49B, CyPA, Cytokeratin 18, DDX47, DNAH5, DNALI1, DPAGT1, FAM22A, FOXD4L2-6, FOXQ1, Furin, G6pd2, Gle1, HAS2, Hep B sAg, HS6ST3, HSCARG_NMRAL1, HSPA4L, HuC, IκB-pp40, IFN-α4, IL-12B p70, IL-18, JAM-C, karyopherin α5, karyopherin α7, KRTAP22-2, Krtap4-16, LCE3A, Lck, LMO3, LOC100041291, LOC727949, LRCH4, LRIT3, LRRC3B, MAZ, MD-1, Measles NP, MIP-2α, Myofibroblasts, NFκB p52, NFKBIL1, NFRκB, NQO1, Nucling, OPN, OST48, Peroxin 7, Pez, plakophilin 4, PlGF2, Prohibitin, Properdin, PTPδ, PTPρ, PTPIP51, PYPAF7, R-PE, Ran BP-6, RCAN2, RDH10, Rhox6, Rhox7, Sciellin, SEL-10, Ser/Thr Protein Kinase, SMUG1, SNAI 1, Sox-21, SPARC, Svs1, Svs2, Svs6, syncytin-A, T2R134, T2R17, T6BP, TAAR3, TAAR7A, TCP-1 ζ, TLR10, TMEM9, TNFβ, tNOX, TRADD, Trav9d-1, Tyrosine Kinase, UGT1A6B, USF-2, V1RC2, V1RC21, Vmn2r3, WAVE1, WDR19, and Ythdc1.Activator of:
κB-Ras1, A20, ATP6V0E1, BTG2, casein kinase IIα′, CC10, CD5, Cyclophilin J, Cytokeratin 2p, Dlx-5, DNA pol ε 4, DnaJC5B, EG435927, EG625716, Elastase-3, FAM105B, GSTT4, IκB-pp40, IFN-α11, IFN-αB, IGFBP3, KLHDC7A, LOC100041019, NKRF, Notch 3, NT-4, Oas1d, OTTMUSG00000007655, Smad4, Sulf-1, T2R14, TIMP-2, TIMP-3, TMPRSS2, TNFα-IP 8L3, TRAF7, Vitronectin, WT1, XPC, and ZBTB6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Emodin, 50 mg | sc-202601 | 50 mg | $103.00 | |||
Emodin, 250 mg | sc-202601A | 250 mg | $210.00 | |||
Emodin, 15 g | sc-202601B | 15 g | $6132.00 |