Molecular structure of Emetine dihydrochloride, CAS Number: 316-42-7
Emetine dihydrochloride (CAS 316-42-7)
See product citations (3)
Alternate Names:
6′,7′,10,11-Tetramethoxyemetan 2HCl
Application:
Emetine dihydrochloride is an inhibitor of protein synthesis in eukaryotic cells
CAS Number:
316-42-7
Purity:
≥98%
Molecular Weight:
553.56
Molecular Formula:
C29H40N2O4•2HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Emetine dihydrochloride is the principal alkaloid of epicac, isolated from Uragoga ipecacuanha ground roots. In eukaryotes, emetine dihydrochloride is known to inhibit ribosome movement along mRNA, thus irreversibly blocking protein synthesis. Emetine dihydrochloride may act to block adrenoreceptors, thus inducing hypotension. Emetine dihydrochloride has been reported to interfere with cytometric DNA replication analysis at the early S phase. Emetine dihydrochloride identified as a specific HIF inhibitor via reduced HIF-2alpha protein stability and transcriptional activity.
Emetine dihydrochloride (CAS 316-42-7) References
- Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation. | Burhans, WC., et al. 1991. EMBO J. 10: 4351-60. PMID: 1721870
- Emetine regulates the alternative splicing of Bcl-x through a protein phosphatase 1-dependent mechanism. | Boon-Unge, K., et al. 2007. Chem Biol. 14: 1386-92. PMID: 18096507
- Effect of mycobacteria on sensitivity to the cytotoxic effects of tumor necrosis factor. | Filley, EA. and Rook, GA. 1991. Infect Immun. 59: 2567-72. PMID: 1906841
- Emetine dihydrochloride: a novel therapy for bladder cancer. | Foreman, KE., et al. 2014. J Urol. 191: 502-9. PMID: 24045224
- Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. | Matthews, H., et al. 2013. Malar J. 12: 359. PMID: 24107123
- Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. | Matthews, H., et al. 2017. PLoS One. 12: e0173303. PMID: 28257497
- Lead Optimization of Dehydroemetine for Repositioned Use in Malaria. | Panwar, P., et al. 2020. Antimicrob Agents Chemother. 64: PMID: 31964796
- Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. | Choy, KT., et al. 2020. Antiviral Res. 178: 104786. PMID: 32251767
- Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats. | Su, S., et al. 2021. Physiol Behav. 241: 113565. PMID: 34461130
- Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells. | Kokuho, T., et al. 1995. Immunobiology. 193: 42-58. PMID: 7590862
- Effects of antioxidants on the anti-proliferation induced by protein synthesis inhibitors in human brain tumor cells. | Lee, YS. and Wurster, RD. 1995. Cancer Lett. 93: 157-63. PMID: 7621423
- Effects of myotoxins on skeletal muscle fibers. | Khan, MA. 1995. Prog Neurobiol. 46: 541-60. PMID: 8532852
- Cardiotoxicity of emetine dihydrochloride by calcium channel blockade in isolated preparations and ventricular myocytes of guinea-pig hearts. | Lemmens-Gruber, R., et al. 1996. Br J Pharmacol. 117: 377-83. PMID: 8789394
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Emetine dihydrochloride, 250 mg | sc-202600 | 250 mg | $177.00 |