emerin Antibody (8A1): sc-81552
- emerin Antibody (8A1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length recombinant emerin of human origin
- recommended for detection of emerin of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for emerin Antibody (8A1) for WB applications. These reagents are now offered in bundles with emerin Antibody (8A1) (see ordering information below).
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SEE ALSO...
Emerin Antibody (8A1) is a mouse monoclonal IgG1 antibody that detects emerin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-emerin antibody (8A1) plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function and gene expression regulation. Emerin′s localization at the nuclear membrane allows interaction with the nuclear lamina, a network of proteins that provides mechanical support to the nucleus and organizes chromatin. This structural role is particularly important in muscle cells, where nuclear envelope integrity is vital for muscle function and repair. Mutations in the gene encoding emerin can disrupt these functions, leading to the development of Emery-Dreyfuss muscular dystrophy (EDMD), a condition characterized by muscle weakness and cardiac issues. Emerin monoclonal antibody (8A1) serves as an invaluable tool for researchers studying the pathophysiology of EDMD and the broader implications of nuclear envelope integrity in various diseases.
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emerin Antibody (8A1) References:
- Multiple and surprising new functions for emerin, a nuclear membrane protein. | Bengtsson, L. and Wilson, KL. 2004. Curr Opin Cell Biol. 16: 73-9. PMID: 15037308
- Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential. | Reis-Sobreiro, M., et al. 2018. Cancer Res. 78: 6086-6097. PMID: 30154147
- EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms. | Iyer, A. and Holaska, JM. 2020. Cells. 9: PMID: 32549231
- The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction. | Gómez-Monsivais, WL., et al. 2020. Int J Mol Sci. 21: PMID: 32824881
- Defects in Emerin-Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis. | Liddane, AG., et al. 2021. Mol Cancer Res. 19: 1196-1207. PMID: 33771882
- Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate. | Tang, Y., et al. 2022. Dev Cell. 57: 480-495.e6. PMID: 35150612
- Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments. | Lavenus, SB., et al. 2022. J Cell Sci. 135: PMID: 35362531
- Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation. | Snyers, L., et al. 2022. Mol Biol Cell. 33: ar137. PMID: 36200863
- Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery. | Marano, N. and Holaska, JM. 2022. Front Cell Dev Biol. 10: 1007120. PMID: 36274837
- Acute downregulation of emerin alters actomyosin cytoskeleton connectivity and function. | Jin, Q., et al. 2023. Biophys J. 122: 3690-3703. PMID: 37254483
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
emerin Antibody (8A1) | sc-81552 | 200 µg/ml | $322.00 | |||
emerin Antibody (8A1): m-IgG Fc BP-HRP Bundle | sc-539623 | 200 µg Ab; 10 µg BP | $361.00 | |||
emerin Antibody (8A1): m-IgG1 BP-HRP Bundle | sc-541608 | 200 µg Ab; 20 µg BP | $361.00 |