Molecular structure of EMD 386088 hydrochloride, CAS Number: 54635-62-0
EMD 386088 hydrochloride (CAS 54635-62-0)
Alternate Names:
5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride
Application:
EMD 386088 hydrochloride is a potent SR-6 agonist
CAS Number:
54635-62-0
Purity:
≥99%
Molecular Weight:
283.2
Molecular Formula:
C14H15N2Cl•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
EMD 386088 hydrochloride is a potent SR-6 (5-HT6) receptor agonist (EC50 = 1.0 nM) that displays selectivity to other serotonin receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for SR-6, SR-1D(5-HT1D), SR-1B(5-HT1B), SR-2A(5-HT2A), SR-2C, SR-4, SR-1A and SR-7, respectively). Moderate affinity at SR-3 (IC50 = 34 nM).
EMD 386088 hydrochloride (CAS 54635-62-0) References
- Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. | Riccio, O., et al. 2009. Mol Psychiatry. 14: 280-90. PMID: 18663366
- Role of peripheral and spinal 5-HT6 receptors according to the rat formalin test. | Castañeda-Corral, G., et al. 2009. Neuroscience. 162: 444-52. PMID: 19422883
- E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat. | Kendall, I., et al. 2011. Psychopharmacology (Berl). 213: 413-30. PMID: 20405281
- The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration. | Nikiforuk, A., et al. 2011. Psychopharmacology (Berl). 217: 411-8. PMID: 21499701
- 5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms. | Woods, S., et al. 2012. Br J Pharmacol. 167: 436-49. PMID: 22568655
- The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats. | Nikiforuk, A., et al. 2013. J Psychopharmacol. 27: 469-76. PMID: 23479455
- Pharmacological evaluation of the anxiolytic-like effects of EMD 386088, a partial 5-HT6 receptor agonist, in the rat elevated plus-maze and Vogel conflict tests. | Jastrzębska-Więsek, M., et al. 2014. Neuropharmacology. 85: 253-62. PMID: 24905144
- Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats. | Jastrzębska-Więsek, M., et al. 2015. Naunyn Schmiedebergs Arch Pharmacol. 388: 1079-88. PMID: 26077660
- Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats. | Jastrzębska-Więsek, M., et al. 2016. Naunyn Schmiedebergs Arch Pharmacol. 389: 839-49. PMID: 27106213
- Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammals. | Chang, W., et al. 2016. Proc Natl Acad Sci U S A. 113: E5491-500. PMID: 27573850
- Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor. | Kotańska, M., et al. 2017. Front Neurosci. 11: 50. PMID: 28228713
- 5-HT6 Receptor Agonist and Antagonist Against β-Amyloid-Peptide-Induced Neurotoxicity in PC-12 Cells. | Bokare, AM., et al. 2017. Neurochem Res. 42: 1571-1579. PMID: 28271324
- Undernutrition during pregnancy and lactation increases the number of fos-cells in the reward system in response to a 5-HT6 receptor agonist in male adolescent rats. | da Silva, AAM., et al. 2018. Int J Food Sci Nutr. 69: 488-493. PMID: 28958176
- 5-HT6 receptor agonist and antagonist modulates ICV-STZ-induced memory impairment in rats. | Bokare, AM., et al. 2018. Psychopharmacology (Berl). 235: 1557-1570. PMID: 29502275
- Serotonin 6 receptor modulation reduces locomotor activity in C57BL/6J mice. | Oliver, BL., et al. 2021. Brain Res. 1757: 147313. PMID: 33548271
Activator of:
SR-1B, SR-1D, SR-2A, and SR-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EMD 386088 hydrochloride, 10 mg | sc-203575 | 10 mg | $135.00 | |||
EMD 386088 hydrochloride, 50 mg | sc-203575A | 50 mg | $440.00 |