Date published: 2025-12-1

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Elvitegravir-d6 (Major) (CAS 1131640-69-1)

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Application:
Elvitegravir-d6 (Major) is an inhibitor of human immunodeficiency virus type 1 integrase
CAS Number:
1131640-69-1
Molecular Weight:
453.91
Molecular Formula:
C23H17D6ClFNO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Elvitegravir-d6 is a compound that functions as an integrase inhibitor in experimental applications. It interacts with the integrase enzyme, preventing the integration of viral DNA into the host cell genome. Elvitegravir-D6 (Major) specifically targets the catalytic site of the integrase enzyme, inhibiting its activity and thereby interfering with the replication of the virus. By binding to the integrase enzyme, Elvitegravir-d6 disrupts the process of viral DNA integration, ultimately hindering the ability of the virus to establish a productive infection. Elvitegravir-D6 (Major)′s mechanism of action involves blocking the strand transfer step of the integration process, thereby impeding the viral life cycle. In experimental applications, Elvitegravir-d6 is utilized to study the mechanisms of viral replication and to explore potential strategies for inhibiting viral integration.


Elvitegravir-d6 (Major) (CAS 1131640-69-1) References

  1. HIV integrase, a brief overview from chemistry to therapeutics.  |  Craigie, R. 2001. J Biol Chem. 276: 23213-6. PMID: 11346660
  2. Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.  |  Chen, X., et al. 2008. J Mol Biol. 380: 504-19. PMID: 18565342
  3. A validated assay by liquid chromatography-tandem mass spectrometry for the simultaneous quantification of elvitegravir and rilpivirine in HIV positive patients.  |  Aouri, M., et al. 2013. J Mass Spectrom. 48: 616-25. PMID: 23674286
  4. The development and application of a novel LC-MS/MS method for the measurement of Dolutegravir, Elvitegravir and Cobicistat in human plasma.  |  Penchala, SD., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1027: 174-80. PMID: 27290668
  5. Simultaneous quantification of tenofovir, emtricitabine, rilpivirine, elvitegravir and dolutegravir in mouse biological matrices by LC-MS/MS and its application to a pharmacokinetic study.  |  Prathipati, PK., et al. 2016. J Pharm Biomed Anal. 129: 473-481. PMID: 27497648
  6. Injectable long-acting human immunodeficiency virus antiretroviral prodrugs with improved pharmacokinetic profiles.  |  Krovi, SA., et al. 2018. Int J Pharm. 552: 371-377. PMID: 30308272
  7. Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro.  |  Baba, M., et al. 1987. Antimicrob Agents Chemother. 31: 1613-7. PMID: 3435108
  8. Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors.  |  Chou, TC. and Talalay, P. 1981. Eur J Biochem. 115: 207-16. PMID: 7227366

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Elvitegravir-d6 (Major), 1 mg

sc-207616
1 mg
$360.00