Molecular structure of Ellagic Acid, Dihydrate, CAS Number: 476-66-4
Ellagic Acid, Dihydrate (CAS 476-66-4)
See product citations (8)
Alternate Names:
4,4′,5,5′,6,6′-Hexahydroxydiphenic Acid 2,6,2′,6′-Dilactone
Application:
Ellagic Acid, Dihydrate is a CK2, Topo I and II, FGR, GSK, and PKA inhibitor
CAS Number:
476-66-4
Purity:
≥96%
Molecular Weight:
338.20
Molecular Formula:
C14H6O8•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ellagic Acid, dihydrate is a cell permeable and strong casein kinase 2 (CK2) inhibitor (Ki = 20 nM) which acts as a potent antioxidant and anti-mutagenic. To some extent It has the ability to inhibit human Topo I (DNA topoisomerase I) and Topo II, Lyn, PKA catalytic subunit, Lyk, GSK-3, and FGR. Ellagic acid can also potently inhibit cAK and PKC and slightly inhibits Dyrk1A (DYRK1a), CSK, RET, Flt3, and NPM-ALK (IC50 >40 muM). Ellagic Acid, Dihydrate is an inhibitor of GST.
Ellagic Acid, Dihydrate (CAS 476-66-4) References
- High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits. | Amakura, Y., et al. 2000. J Chromatogr A. 896: 87-93. PMID: 11093643
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. | Cozza, G., et al. 2006. J Med Chem. 49: 2363-6. PMID: 16610779
- The crystal and molecular structure of ellagic acid dihydrate: a dietary anti-cancer agent. | Rossi, M., et al. 1991. Carcinogenesis. 12: 2227-32. PMID: 1747921
- Spectrofluorimetric determination of ellagic acid in brandy. | Sádecká, J. and Tóthová, J. 2012. Food Chem. 135: 893-7. PMID: 22953802
- Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions. | Li, B., et al. 2013. Carbohydr Polym. 92: 1443-50. PMID: 23399175
- Promotional effects of new types of additives on fat crystallization. | Yoshikawa, S., et al. 2014. J Oleo Sci. 63: 333-45. PMID: 24599107
- CARM1 modulators affect epigenome of stem cells and change morphology of nucleoli. | Franek, M., et al. 2015. Physiol Res. 64: 769-82. PMID: 26047373
- Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms. | Kang, I., et al. 2016. Adv Nutr. 7: 961-72. PMID: 27633111
- Structural Study on Fat Crystallization Process Heterogeneously Induced by Graphite Surfaces. | Kaneko, F., et al. 2020. Molecules. 25: PMID: 33086514
- Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water. | Mukhtar, H., et al. 1986. Cancer Res. 46: 2262-5. PMID: 3486036
- The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro. | Constantinou, A., et al. 1995. Nutr Cancer. 23: 121-30. PMID: 7644381
- Novel inhibitors of 3-phosphoglycerate kinase. | Hickey, MJ., et al. 1995. Biochem Soc Trans. 23: 607S. PMID: 8654792
- Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol. | Wang, BH., et al. 1998. Planta Med. 64: 195-9. PMID: 9581512
Inhibitor of:
β-glucuronidase, β-synuclein, κ-casein, 1110001A16Rik, 1110017F19Rik, 1190007F08Rik, 1600014C23Rik, 17β-HSD4, 1700008P20Rik, 1700017D01Rik, 1700023F06Rik, 1700026J04Rik, 1700129C05Rik, 1810024B03Rik, 2010315B03Rik, 2210010C04Rik, 2210016F16Rik, 2210020M01Rik, 2300003K06Rik, 2410017P09Rik, 4930415L06Rik, 4930428E23Rik, 4930467E23Rik, 4930523C07Rik, 4930579G24Rik, 4933437F05Rik, 8-hydroxyguanine, A-kinase anchoring protein (AKAP), A630033E08Rik, Aflatoxin B1, Aflatoxin B2, AFP Receptor, AKR7A2, AKR7A3, Aldoart1, Angptl4, AP1, APOBEC3B, apoL9b, Arbp, ART4, Benzo[a]pyrene, BPDE-DNA, C4orf47, C9orf21, Calgranulin B, CapZ-3, Carbonyl reductase 3, Casein Kinase, Casein Kinase II, casein kinase II alpha, casein kinase IIβ, CBR4, CD66CE, CD8α, Cks1, Ckt2, claudin-4, CRISP-1, CSHL1, CTLA-2β, CXorf30, CXorf49B, CXorf51, CYB561D1, CYP1B1, CYP2A13, CYP2A7, cystatin 11, Cytokeratin 23, DC-SIGN, DC-SIGN/CD209, Dcun1D2, DDT, DDX12, DDX34, DDX49, DDX50, DDX60L, DFF-45, DHX32, DUSP4, E2F-2, EFO1, EG668526, ephrin-B3, ESAT6, Esp38, FAM22A, FN3K, FOXD4L2-6, Gα gust, GalNAc-T8, GalNAc4ST-1, GATA-4, GD3 Synthase, glutathione S-transferase mu (GSTM), Gm10471, Gm14195, GOLGA8E-G, GRXCR1, GST, Gsta1, GSTCD, GSTM4, GSTM5, GSTM6, GSTO2, GSTP1, Gstp2, GSTT2B, GSTT4, HHV-8 K-bZIP, Histone cluster 2 H3C, Histone cluster 2 H3D, Histone cluster 2 H4B, HIV-1 Gag, HMG-20A, HMG-I/HMG-Y, HNF-6, hnRNP I, hornerin, HPV16 E1, HPV16 E6, HPV16 L2, HS3ST5, HS6ST2, HSP 47, HYAL3, IL-12B p70, IL-3β, Kremen-2, KRTAP13, KRTAP15-1, KRTAP22-2, Krtap4-16, LOXL1, LTrp7, Luciferase, Ly6G6c, MASP-2, MB67_CAR1/2, MBD3L3, MDA5, MGST3, MOSC2, MOV10, MsrB3, MTCP-1, Mucin, MYLK, NAT-1, NAT-14, NCoA-3, NEI, NF-E2, NKHC1, nm23-M6, NQO1, Nth2, Nucling, OGG1, Olr267, OST48, OTTMUSG00000010546, P protein, PAPST2, parathymosin, PCNA, PEA3, PGP-I, Pim-2, Placental lactogen Iα, Placental lactogen II, Pmel17, PRMT7, PRX2, PSG11, Psg23, Psg25, Psg26, Psg27, Psg28, PSGL-1, PTER, PTPN13LY, PTTG, RAP1, RASSF1A, RDH11, RDH7, Reg Iα, Reg Iβ, Rhox3g, RNase 4, S-100 β chain, SATB1, Sciellin, SCP2, Ser/Thr Protein Kinase, SerpinA1c, SerpinA3m, SerpinB12, SET8, SIRP-α1, SKN-1, SMUG1, SnoN_SnoN2_SnoA, SPANX-B2, SPEN, SPOP, SPRR2, Sptrx-1, SR-BI, SSXB9, stefin A1, Sulf-1, SULT1A2, SULT1C2, SULT1D1, SULT2A5, SULT2B10, SV40 T Ag, Syndecan-2, T2R20, T2R29, T2R37, TBG, Thrombospondin 2, TMPRSS11C, TNF Superfamily (TNFSF), Topo I, TPST-1, TPST-2, TRAIL, TRM12, TRP1, TRP2, Tyrosinase, TYW1B, U2AF26, UGT1A4, UGT1A6B, UGT1A7, UGT2A1, UGT2A2, UGT2B11, UGT2B36, UGT2B38, UGT2B4, UGT3A1, UGT3A2, UGTREL1, USF-1, V1RC20, V1RC23, V1RC24, V1RC25, V1RC26, V1RC28, V1rc29, V1RC33, V1RF1, V1RF3, VEGF-B, VEGI, Wnt-10b, YY1, ZFP11, ZFP110, ZFP113, ZFP119, ZNF191, ZNF217, ZNF527, and ZNF737.Activator of:
α2ML1, β-defensin 124, β-defensin 129, β-defensin 130, β-Glucoronidase, 2810403A07Rik, 9G8, A730069N07Rik, ADAM9, AI481877, ALKBH3, ALY, ANT3, ARGFX, ARH1, ARHI, ASCC2, B7-2, BLM, C1orf158_1700012P22Rik, CASC5, casein kinase IIα′, CES7, CMBL, COL18A1, Collagen α2 Type VI, CRYZL1, CSB, CST9L, CstF-64T, CYP2B23, CYP2C19, CYP2T4, Cyp3a44, DDX24, DNA pol ν, DNAH2, DnaJB3, DnaJC5B, DNAS1L3, DNASE1L2, Dynactin 6, EG432879, ELOF1, Factor H, FAM55C, FANCC, FANCF, FANCL, FILIA, FRP-1, GβL, GPN2, GPx-2, GSDMC4, GST, Gsta1, GSTA2, GSTA4, GSTK1, GSTM3, GSTM7, GSTT1, GSTT2, Hepassocin, Histone cluster 1 H2BO, Histone cluster 2 H4B, HUGT2, IL-4Rα, Ime2, IQCF1, IRS-1, Jaz, JWA, KIAA0090, KIAA0754, Klkb1, KRTAP10-2, KRTAP16-7, KRTAP9-1, Lex A, Lipocalin-5, LOC100039934, LOC100040857, LOC100041139, LOC145837, LOC643749, LOC646567, MALT1, MARCH1, MBPH, MEK-4, MGST2, mKIAA1530, MLH1, MRP1, MSH2_Msh2, Myt 1, NALP9A, NAT-13, NBK, Nebulin, Neurogenin 2, Nrf3, Nucleoredoxin, OAT6, OR2M5, OR2T29, OR5K2, OTTMUSG00000011792, PI 3-kinase p110γ, PIG-M, Pin1l, PON3, PRC1, PSMD5, Rad30, RASSF1A, RASSF1B, RECK, Reg lllα, REG3α, Ribosomal Protein L30, RUNX3, SCCA1, SerpinA1e, SerpinA3k, Serpinb3a, SH3BGRL, Spaca6, SPINK6, SRP9, SULT1, SULT2A4, SULT2A5, SULT4A1, TEDDM1, Tel1, TGFβ, TGIF2LX2, TGR5, TIMP-2, TIP30, TMPRSS11D, Top3, TRM61, U2 snRNP A, UGT1A1, UGT1A10, UGT1A5, UGT1A6, UGT1A6A, UGT1A9, UGT2A2, UGT2A3, UGT2B, UGT2B10, UGT2B11, UGT2B28, UGT2B35, UGT2B37, UGT2B4, UGT3A1, UGT3A2, VRK3, WDR13, WDR40A, XIIα, XPA, XPC, XPG, ZCWPW2, ZNF625, and ZNF687.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ellagic Acid, Dihydrate, 500 mg | sc-202598 | 500 mg | $58.00 | |||
Ellagic Acid, Dihydrate, 5 g | sc-202598A | 5 g | $95.00 | |||
Ellagic Acid, Dihydrate, 25 g | sc-202598B | 25 g | $245.00 | |||
Ellagic Acid, Dihydrate, 100 g | sc-202598C | 100 g | $727.00 |