Molecular structure of Eliprodil, CAS Number: 119431-25-3
Eliprodil (CAS 119431-25-3)
Alternate Names:
α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
Application:
Eliprodil is a non-competitive NR2B-selective NMDA antagonist
CAS Number:
119431-25-3
Molecular Weight:
347.86
Molecular Formula:
C20H23ClFNO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Eliprodil is a non-competitive NMDA receptor antagonist which acts at the polyamine modulatory site. Eliprodil is selective for NMDA epsilon 2 (NR2B-containing receptors) over NR2A- and NR2C-containing receptors (IC50 values are 1, > 100 and > 100 μM respectively) in addition to acting as a Sigma Receptor (σ1 ligand) (Ki = 0.013 μM). Eliprodil antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Furthermore, Eliprodil is reported to act as a neuroprotective.
Eliprodil (CAS 119431-25-3) References
- Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats. | Wlaź, P., et al. 1999. Neuropharmacology. 38: 243-51. PMID: 10218865
- Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells. | Pang, IH., et al. 1999. Invest Ophthalmol Vis Sci. 40: 1170-6. PMID: 10235550
- Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia. | Kapin, MA., et al. 1999. Invest Ophthalmol Vis Sci. 40: 1177-82. PMID: 10235551
- Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits. | Thomas, JD., et al. 2004. Psychopharmacology (Berl). 175: 189-95. PMID: 15064913
- Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. | Lengyel, C., et al. 2004. Br J Pharmacol. 143: 152-8. PMID: 15302678
- The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons. | Biton, B., et al. 1994. Eur J Pharmacol. 257: 297-301. PMID: 8088348
- Motor actions of eliprodil in the normal and monoamine-depleted mouse: a role in the treatment of Parkinson's disease? | Brooks, S., et al. 1996. J Neural Transm (Vienna). 103: 737-48. PMID: 8836935
- The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. | Bath, CP., et al. 1996. Eur J Pharmacol. 299: 103-12. PMID: 8901012
- Stereoselective determination of unchanged and glucuroconjugated eliprodil, a new anti-ischaemic drug, in human plasma and urine by precolumn derivatization and column-switching high-performance liquid chromatography with fluorescence detection. | Malavasi, B., et al. 1996. J Chromatogr A. 729: 323-33. PMID: 9004957
- Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage. | Reyes, M., et al. 1998. Brain Res. 782: 212-8. PMID: 9519265
- The effect of eliprodil on the evolution of a focal cerebral ischaemia in vivo. | Ibarrola, D., et al. 1998. Eur J Pharmacol. 352: 29-35. PMID: 9718264
- Place conditioning of mice with the NMDA receptor antagonists, eliprodil and dizocilpine. | Sukhotina, I., et al. 1998. Eur J Pharmacol. 362: 103-10. PMID: 9874159
- Eliprodil stimulates CNS myelination: new prospects for multiple sclerosis? | Demerens, C., et al. 1999. Neurology. 52: 346-50. PMID: 9932955
Inhibitor of:
NDST, NMDA, NMDA epsilon 2, and NMDAε1.Activator of:
densin-180.Substrate of:
Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eliprodil, 10 mg | sc-203939 | 10 mg | $145.00 | |||
Eliprodil, 50 mg | sc-203939A | 50 mg | $510.00 |