Molecular structure of Elbfluorene
Elbfluorene
Alternate Names:
1-Aza-9-oxafluorene 5b
Application:
Elbfluorene is a selective cyclin-dependent kinase inhibitor
Molecular Weight:
303.31
Molecular Formula:
C19H13NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective inhibitor of CDK1/cyclin B with some P-glycoprotein-modulating properties. Weakly inhibits CDK5/p25 with no effect on CDK2/cyclin E and CDK4/cyclin D1.
Elbfluorene References
- Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties. | Brachwitz, K., et al. 2003. J Med Chem. 46: 876-9. PMID: 12593668
- Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes. | Voigt, B., et al. 2005. Bioorg Med Chem Lett. 15: 823-5. PMID: 15664865
- A new route to 3-acyl-2-aminobenzofurans: palladium-catalysed cycloisomerisation of 2-(cyanomethyl)phenyl esters. | Murai, M., et al. 2009. Chem Commun (Camb). 3466-8. PMID: 19503906
- Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. | Tell, V., et al. 2012. Bioorg Med Chem Lett. 22: 6914-8. PMID: 23039927
- Chemoselective arylation of phenols with bromo-nitroarenes: synthesis of nitro-biaryl-ols and their conversion into benzofurans and carbazoles. | Kumar, A., et al. 2014. Chem Commun (Camb). 50: 9481-4. PMID: 25007753
- How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases? | Jorda, R., et al. 2018. J Med Chem. 61: 9105-9120. PMID: 30234987
- MnO2-Mediated Oxidative Cyclization of 'Formal' Schiff's Bases: Easy Access to Diverse Naphthofuro-Annulated Triazines. | Fatykhov, RF., et al. 2022. Molecules. 27: PMID: 36296698
- Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence. | Clarkson, GJ. and Roesner, S. 2023. J Org Chem. 88: 684-689. PMID: 36484714
- AlCl3 induced C-arylation/cyclization in a single pot: a new route to benzofuran fused N-heterocycles of pharmacological interest[J]. | Kumar K S, Adepu R, Kapavarapu R. 2012,. Tetrahedron Letters,. 53(9):: 1134-1138.
- Synthesis of Some 3‐(4‐Aryl‐benzofuro [3, 2‐b] pyridin‐2‐yl) coumarins and Their Antimicrobial Screening[J]. | Patel A K, Patel N H, Patel M A,. 2012. Journal of Heterocyclic Chemistry. 49(3):: 504-510.
Inhibitor of:
Cdc2, cyclin B, Ser/Thr Protein Kinase, and Transcription Factor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elbfluorene, 1 mg | sc-221585 | 1 mg | $200.00 | |||
Elbfluorene, 5 mg | sc-221585A | 5 mg | $400.00 |