Molecular structure of Elastatinal, CAS Number: 51798-45-9
Elastatinal (CAS 51798-45-9)
See product citations (4)
Alternate Names:
(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1- carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-ox
Application:
Elastatinal is an elastase inhibitor
CAS Number:
51798-45-9
Molecular Weight:
512.56
Molecular Formula:
C21H36N8O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Elastatinal is a protease inhibitor. Studies have demonstrated that Elastatinal can effectively inhibit phenylmethylsulfonyl fluoride (PMSF, sc-3597) degradation of the H1 histone and high mobility group (HMG) proteins. Elastatinal is an elastase inhibitor and has exhibited the ability to inhibit poliovirus and rhinovirus 2A proteinases in vitro. Additionally, it has no effect on DNA repair and UV-induced sister chromatid exchanges, and inhibits the cleavages found at Ala-Ala bonds in peptides that represent the capsid/nucleocapsid site. Elastatinal is an inhibitor of Neutrophil Elastase.
Elastatinal (CAS 51798-45-9) References
- Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines. | Menéndez-Arias, L., et al. 1992. J Biol Chem. 267: 11392-8. PMID: 1375941
- Phenylmethylsulfonyl fluoride stimulates proteolysis of nuclear proteins from chick liver. | Oka, T., et al. 1992. Biochem Biophys Res Commun. 189: 179-83. PMID: 1449471
- Elastase secretion in Acanthamoeba polyphaga. | Ferreira, GA., et al. 2009. Acta Trop. 112: 156-63. PMID: 19632188
- Identification and expression of an elastase homologue in Branchiostoma belcheri with implications to the origin of vertebrate pancreas. | Sun, T., et al. 2010. Mol Biol Rep. 37: 3303-9. PMID: 19908163
- A unique elastase in human blood platelets. | James, HL., et al. 1985. J Clin Invest. 76: 2330-7. PMID: 2416778
- Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins. | Maxson, T., et al. 2016. J Am Chem Soc. 138: 15157-15166. PMID: 27797509
- Isolation of a putative virulence agent, cytotoxic serine-elastase, from a newly isolated Pseudomonas aeruginosa ZuhP13. | Kotb, E., et al. 2019. J Biosci. 44: PMID: 30837358
- Medullasin enhances human natural killer cell activity. | Aoki, Y., et al. 1982. J Clin Invest. 69: 1223-30. PMID: 6177714
- A zinc metalloendopeptidase associated with dog pancreatic membranes. | Mumford, RA., et al. 1980. J Biol Chem. 255: 2227-30. PMID: 6987219
- Cytotoxic effects of protease inhibitors on human cells. 2. Effect of elastatinal. | Yagi, T., et al. 1980. Cancer Lett. 10: 301-7. PMID: 7191773
- Elastatinal and leupeptin: effects on u.v.-induced mutation and sister-chromatid exchanges in Chinese hamster cells. | Paul, P. and Fujiwara, Y. 1981. Carcinogenesis. 2: 255-9. PMID: 7273311
- Prevention of normal mouse uterine maturation by antipain and elastatinal: suppression of peroxidase activity. | Katz, J., et al. 1978. Endocr Res Commun. 5: 325-34. PMID: 752635
- Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors. | Molla, A., et al. 1993. J Virol. 67: 4688-95. PMID: 8392608
Inhibitor of:
granzyme G, Neutrophil Elastase, Pronase, and PRSSL1.Activator of:
CRISP-8, and elastin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elastatinal, 5 mg | sc-201272 | 5 mg | $87.00 | |||
Elastatinal, 25 mg | sc-201272A | 25 mg | $346.00 |