Molecular structure of Elastase Inhibitor II
Elastase Inhibitor II
Application:
Elastase Inhibitor II is a strong, irreversible human neutrophil elastase (HNE) inhibitor
Molecular Weight:
474.9
Molecular Formula:
C20H31ClN4O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Elastase Inhibitor II is a compound that functions by inhibiting the activity of elastase, a protease enzyme involved in the breakdown of elastin in connective tissues. This inhibitor acts by binding to the active site of elastase, preventing its interaction with elastin and subsequent degradation. By doing so, Elastase Inhibitor II helps to maintain the structural integrity of connective tissues and prevents excessive tissue damage. Elastase Inhibitor II exerts its mode of action at the molecular level, interfering with the catalytic activity of elastase and disrupting its normal function.
Elastase Inhibitor II References
- The significance of carbohydrates on G-CSF: differential sensitivity of G-CSFs to human neutrophil elastase degradation. | Carter, CR., et al. 2004. J Leukoc Biol. 75: 515-22. PMID: 14657210
- Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway. | Chen, HC., et al. 2004. J Biomed Sci. 11: 49-58. PMID: 14730209
- Human neutrophil-derived elastase induces airway smooth muscle cell proliferation. | Huang, CD., et al. 2004. Life Sci. 74: 2479-92. PMID: 15010259
- Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats. | Mayerle, J., et al. 2005. Gastroenterology. 129: 1251-67. PMID: 16230078
- Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. | Lee, KY., et al. 2006. Am J Respir Cell Mol Biol. 35: 407-14. PMID: 16690986
- Structural and functional comparison of native pentameric, denatured monomeric and biotinylated C-reactive protein. | Taylor, KE. and van den Berg, CW. 2007. Immunology. 120: 404-11. PMID: 17163961
- Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice. | Sakashita, A., et al. 2007. Eur J Pharmacol. 571: 62-71. PMID: 17599828
- Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor. | Ho, SC., et al. 2009. J Immunol. 183: 411-20. PMID: 19542452
- Trauma-activated polymorphonucleated leukocytes damage endothelial progenitor cells: probable role of CD11b/CD18-CD54 interaction and release of reactive oxygen species. | Henrich, D., et al. 2011. Shock. 36: 216-22. PMID: 21610569
- The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release. | Okochi, Y., et al. 2016. J Leukoc Biol. 99: 7-19. PMID: 25990245
- Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation. | Seif, K., et al. 2018. Thromb Haemost. 118: 2074-2085. PMID: 30419595
- Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung. | Genschmer, KR., et al. 2019. Cell. 176: 113-126.e15. PMID: 30633902
- Isolation of a putative virulence agent, cytotoxic serine-elastase, from a newly isolated Pseudomonas aeruginosa ZuhP13. | Kotb, E., et al. 2019. J Biosci. 44: PMID: 30837358
- Pancreatic Inflammation and Proenzyme Activation Are Associated With Clinically Relevant Postoperative Pancreatic Fistulas After Pancreas Resection. | Wüster, C., et al. 2020. Ann Surg. 272: 863-870. PMID: 32833754
- Trypsin and elastase inhibitors from bitter gourd (Momordica charantia LINN.) seeds: purification, amino acid sequences, and inhibitory activities of four new inhibitors. | Hamato, N., et al. 1995. J Biochem. 117: 432-7. PMID: 7608135
Inhibitor of:
Elastase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elastase Inhibitor II, 5 mg | sc-294466 | 5 mg | $327.00 | |||
Elastase Inhibitor II, 10 mg | sc-294466A | 10 mg | $629.00 |