Molecular structure of Elaiophylin, CAS Number: 37318-06-2
Elaiophylin (CAS 37318-06-2)
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Alternate Names:
Azalomycin-B; Gopalamicin; Salbomycin
Application:
Elaiophylin is a macrolide antibiotic with immunosuppresive activity
CAS Number:
37318-06-2
Purity:
≥95%
Molecular Weight:
1025.27
Molecular Formula:
C54H88O18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Elaiophylin is a highly characteristic macrolide antibiotic that was first isolated from a culture of Streptomyces melanosporus. Elaiophylin demonstrates antifungal activity when combined with metabolite rapamycin (sc-3504). Elaiophylin shows shown cytotoxicity against mammalian tumor cells, protozoa, nematodes and antibacterial activity aganst gram-positive bacteria. The compound has also displayed immunosuppressive activity through inhibition of B-cell stimulation and inhibiting proliferation of lymphocytes stimulated by mitogens. Elaiophylin has been found to have antihelminthic to inhibit nitric oxide synthesis. Elaiophylin is an inhibitor of 5 alpha-Reductase and NOS.
Elaiophylin (CAS 37318-06-2) References
- SNA-4606-1, a new member of elaiophylins with enzyme inhibition activity against testosterone 5 alpha-reductase. | Nakakoshi, M., et al. 1999. J Antibiot (Tokyo). 52: 175-7. PMID: 10344572
- Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes. | Grigoriev, PA., et al. 2001. Bioelectrochemistry. 54: 11-5. PMID: 11506969
- Biotechnological preparation of the elaiophylin. | Cikosová, M., et al. 2004. Folia Microbiol (Praha). 49: 731-6. PMID: 15881411
- Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. | Zhao, X., et al. 2015. Autophagy. 11: 1849-63. PMID: 25893854
- The complete genome sequence of Streptomyces autolyticus CGMCC 0516, the producer of geldanamycin, autolytimycin, reblastatin and elaiophylin. | Yin, M., et al. 2017. J Biotechnol. 252: 27-31. PMID: 28472671
- Antiangiogenic Potential of Microbial Metabolite Elaiophylin for Targeting Tumor Angiogenesis. | Lim, HN., et al. 2018. Molecules. 23: PMID: 29498688
- Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity. | Siddiqui, FA., et al. 2021. Biomolecules. 11: PMID: 34199986
- Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. | Bao, R., et al. 2021. Cell Death Dis. 12: 972. PMID: 34671010
- Crossregulation of rapamycin and elaiophylin biosynthesis by RapH in Streptomyces rapamycinicus. | He, W., et al. 2022. Appl Microbiol Biotechnol. 106: 2147-2159. PMID: 35218390
- Elaiophylin Inhibits Tumorigenesis of Human Uveal Melanoma by Suppressing Mitophagy and Inducing Oxidative Stress via Modulating SIRT1/FoxO3a Signaling. | Zhu, X., et al. 2022. Front Oncol. 12: 788496. PMID: 35387119
- Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation. | Li, GN., et al. 2022. Signal Transduct Target Ther. 7: 317. PMID: 36097006
- Metabolic products of microorganisms. 200 Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger. | Fiedler, HP., et al. 1981. J Antibiot (Tokyo). 34: 1107-18. PMID: 7035426
- Elaiophylin as a rumen fermentation efficiency enhancer. | Liu, CM., et al. 1993. J Antibiot (Tokyo). 46: 350-2. PMID: 8468252
Inhibitor of:
5 α-Reductase, and NOS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elaiophylin, 1 mg | sc-202147 | 1 mg | $196.00 | |||
Elaiophylin, 5 mg | sc-202147A | 5 mg | $449.00 | |||
Elaiophylin, 10 mg | sc-202147B | 10 mg | $555.00 | |||
Elaiophylin, 25 mg | sc-202147C | 25 mg | $1088.00 | |||
Elaiophylin, 50 mg | sc-202147D | 50 mg | $1983.00 | |||
Elaiophylin, 100 mg | sc-202147E | 100 mg | $3488.00 |