Elaiophylin is a highly characteristic macrolide antibiotic that was first isolated from a culture of Streptomyces melanosporus. Elaiophylin demonstrates antifungal activity when combined with metabolite rapamycin (sc-3504). Elaiophylin shows shown cytotoxicity against mammalian tumor cells, protozoa, nematodes and antibacterial activity aganst gram-positive bacteria. The compound has also displayed immunosuppressive activity through inhibition of B-cell stimulation and inhibiting proliferation of lymphocytes stimulated by mitogens. Elaiophylin has been found to have antihelminthic to inhibit nitric oxide synthesis. Elaiophylin is an inhibitor of 5 α-Reductase and NOS.
1. Fiedler, H.P., et al. 1981. J. Antibiot. 34: 1107-1118. PMID: 7035426 2. Nakakoshi, M., et al. 1999. J. Antibiot. 52: 175-177. PMID: 10344572 3. Grigoriev, P.A., et al. 2001. Bioelectrochemistry. 54: 11-15. PMID: 11506969 4. Cikosová, M., et al. 2004. Folia Microbiol. 49: 731-736. PMID: 15881411
Soluble in ethanol (5 mg/ml at 25° C), methanol, DMF, DMSO (49 mg/ml at 25° C), and water (<1 mg/ml at 25° C).
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GrigorievGrigoriev, PA. et al. (PubMed 11506969) found that Elaiophylin, a macrolide antibiotic with antifungal, antitumor, anithelminthic and immunosuppressant properties, forms stable, long-lasting cation selective ion channels in planar lipid bilayer membranes prepared from soybean phosphatidylcholine. -SCBT Publication Review
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