Elaiophylin CAS: 37318-06-2
MF: C54H88O18
MW: 1025.27
A macrolide antibiotic with immunosuppresive activity.

Elaiophylin (CAS 37318-06-2)

Elaiophylin | CAS 37318-06-2 is rated 5.0 out of 5 by 1.
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Alternate Names: Azalomycin-B; Gopalamicin; Salbomycin
Application: Elaiophylin is a macrolide antibiotic with immunosuppresive activity
CAS Number: 37318-06-2
Purity: ≥95%
Molecular Weight: 1025.27
Molecular Formula: C54H88O18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Elaiophylin is a highly characteristic macrolide antibiotic that was first isolated from a culture of Streptomyces melanosporus. Elaiophylin demonstrates antifungal activity when combined with metabolite rapamycin (sc-3504). Elaiophylin shows shown cytotoxicity against mammalian tumor cells, protozoa, nematodes and antibacterial activity aganst gram-positive bacteria. The compound has also displayed immunosuppressive activity through inhibition of B-cell stimulation and inhibiting proliferation of lymphocytes stimulated by mitogens. Elaiophylin has been found to have antihelminthic to inhibit nitric oxide synthesis. Elaiophylin is an inhibitor of 5 α-Reductase and NOS.


References

1. Fiedler, H.P., et al. 1981. J. Antibiot. 34: 1107-1118. PMID: 7035426
2. Nakakoshi, M., et al. 1999. J. Antibiot. 52: 175-177. PMID: 10344572
3. Grigoriev, P.A., et al. 2001. Bioelectrochemistry. 54: 11-15. PMID: 11506969
4. Cikosová, M., et al. 2004. Folia Microbiol. 49: 731-736. PMID: 15881411

Physical State :
Solid
Derived From :
Streptomyces
Solubility :
Soluble in ethanol (5 mg/ml at 25° C), methanol, DMF, DMSO (49 mg/ml at 25° C), and water (<1 mg/ml at 25° C).
Storage :
Store at -20° C
Boiling Point :
1080.48° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
K562 human leukemia cells: IC50 = 0.19 µM; L929 mouse fibroblast cells: IC50 = 0.29 µM; Plasmodium falciparum K1a: IC50 = 0.36 µM; Trypanosoma brucei brucei GUTat 3.1 strains: IC50 = 0.45 µM; MRC-5 cells: IC50 = 0.85 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CL8380000
PubChem CID :
6444206
MDL Number :
MFCD01939399

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Certificate of Analysis

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Elaiophylin (CAS 37318-06-2)  Product Citations

See how others have used Elaiophylin (CAS 37318-06-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 11506969  Grigoriev, PA. et al. 2001. Bioelectrochemistry. 54: 11-15.

Citations 1 to 1 of 1 total

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, Elaiophylin (CAS 37318-06-2), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Grigoriev Grigoriev, PA. et al. (PubMed 11506969) found that Elaiophylin, a macrolide antibiotic with antifungal, antitumor, anithelminthic and immunosuppressant properties, forms stable, long-lasting cation selective ion channels in planar lipid bilayer membranes prepared from soybean phosphatidylcholine. -SCBT Publication Review
Date published: 2015-04-04
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