Molecular structure of Elaidamide, CAS Number: 4303-70-2
Elaidamide (CAS 4303-70-2)
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Alternate Names:
(9E)-9-Octadecenamide; Elaidic acid amide
Application:
Elaidamide is a sleep-inducing fatty acid amide found naturally in cerebrospinal fluid
CAS Number:
4303-70-2
Molecular Weight:
281.48
Molecular Formula:
C18H35NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Elaidamide is a structural analog of oleamide (cis-9,10-octadecenoamide) which is a sleep-inducing fatty acid amide found naturally in cerebrospinal fluid. It effectively inhibits rat microsomal epoxide hydrolase and also exerts inhibitory effects on porcine pancreatic and human synovial phospholipase A2 (PLA2). Moreover, in vivo experiments have shown that elaidamide, administered at a dosage of 10 mg per animal, induces natural sleep patterns in rats.
Elaidamide (CAS 4303-70-2) References
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- Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. | Morisseau, C., et al. 2008. Chem Res Toxicol. 21: 951-7. PMID: 18363382
- 20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site. | Chen, Y., et al. 2009. J Pharmacol Exp Ther. 331: 1137-45. PMID: 19762546
- Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. | Pham, MH., et al. 2011. Drug Metab Lett. 5: 73-84. PMID: 21457135
- Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells. | Farrell, EK., et al. 2012. J Lipid Res. 53: 247-56. PMID: 22095832
- Inhibitory action of linoleamide and oleamide toward sarco/endoplasmic reticulum Ca2+-ATPase. | Yamamoto, S., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 3399-3405. PMID: 27595606
- Multidimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry for Identification of Bioactive Fatty Acyl Derivatives. | Divito, EB., et al. 2016. Front Physiol. 7: 608. PMID: 28018237
- Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate. | Marcocci, L. and Suzuki, YJ. 2019. Antioxidants (Basel). 8: PMID: 31083512
- Interference of oleamide with analytical and bioassay results. | Jug, U., et al. 2020. Sci Rep. 10: 2163. PMID: 32034225
- Oleamide, a Bioactive Compound, Unwittingly Introduced into the Human Body through Some Plastic Food/Beverages and Medicine Containers. | Naumoska, K., et al. 2020. Foods. 9: PMID: 32369935
- Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam. | Barnette, DA., et al. 2020. Toxicology. 440: 152478. PMID: 32437779
- Development of a Microfluidic Platform for Trace Lipid Analysis. | Davic, A. and Cascio, M. 2021. Metabolites. 11: PMID: 33668377
- Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity. | Radman, S., et al. 2022. Mar Drugs. 20: PMID: 35049912
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elaidamide, 100 mg | sc-211406 | 100 mg | $333.00 | |||
Elaidamide, 250 mg | sc-211406A | 250 mg | $666.00 |