Molecular structure of eIF-2α Inhibitor II, Sal003, CAS Number: 1164470-53-4
eIF-2α Inhibitor II, Sal003 (CAS 1164470-53-4)
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Alternate Names:
3-phenyl-N-[2,2,2-trichloro-1-[(4-chlorophenyl)carbamothioylamino]ethyl]prop-2-enamide
Application:
eIF-2α Inhibitor II, Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal
CAS Number:
1164470-53-4
Purity:
≥98%
Molecular Weight:
463.21
Molecular Formula:
C18H15Cl4N3OS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
eIF-2α Inhibitor II, Sal003 is a potent cell-permeable analog of the eIF2alpha phosphatase inhibitor salubrinal (sc-202332) with enhanced aqueous solubility. This compound may act to prevent dephosphorylation of eIF-2alpha which may act to regulate the late phase of long-term potentiation (LTP) and memory (LTM). This enhanced phosphorylated state of eIF-2alpha is shown to prevent L-LTP and suppress memory in mice.
eIF-2α Inhibitor II, Sal003 (CAS 1164470-53-4) References
- Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. | Robert, F., et al. 2006. Mol Biol Cell. 17: 4632-44. PMID: 16928960
- eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. | Costa-Mattioli, M., et al. 2007. Cell. 129: 195-206. PMID: 17418795
- A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway. | Kazemi, S., et al. 2007. Mol Biol Cell. 18: 3635-44. PMID: 17596516
- The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. | Baltzis, D., et al. 2007. J Biol Chem. 282: 31675-87. PMID: 17785458
- PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation. | Raven, JF., et al. 2008. J Biol Chem. 283: 3097-3108. PMID: 18063576
- Consolidation of object recognition memory requires HRI kinase-dependent phosphorylation of eIF2α in the hippocampus. | ILL-Raga, G., et al. 2013. Hippocampus. 23: 431-6. PMID: 23418065
- Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. | Ma, T., et al. 2013. Nat Neurosci. 16: 1299-305. PMID: 23933749
- eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. | Jian, M., et al. 2014. J Neurosci. 34: 10010-21. PMID: 25057203
- Neuroprotection and Blood-Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury. | Barreda-Manso, MA., et al. 2017. J Cell Physiol. 232: 1501-1510. PMID: 27753092
- Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. | Ju, SM., et al. 2017. Int J Mol Med. 40: 1957-1964. PMID: 29039478
- Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving. | Werner, CT., et al. 2018. J Neurosci. 38: 2683-2697. PMID: 29431650
- PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance. | Dadey, DYA., et al. 2018. Mol Cancer Res. 16: 1447-1453. PMID: 29991528
- An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy. | Darini, C., et al. 2019. Nat Commun. 10: 2139. PMID: 31086176
- Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation. | Fujita, R., et al. 2021. Development. 148: PMID: 33318147
- Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats. | Chen, Y., et al. 2023. Front Pharmacol. 14: 1095307. PMID: 36744257
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eIF-2α Inhibitor II, Sal003, 5 mg | sc-221582 | 5 mg | $200.00 |