EHT 1864 (CAS 754240-09-0)

EHT 1864 is a highly potent and selective Rac1 inhibitor, showcasing a remarkable affinity for the Rac family of GTPases, which are pivotal in the regulation of cell shape, migration, and growth through their control of actin cytoskeleton dynamics. Its mechanism of action is predicated on the stabilization of Rac in its inactive GDP-bound state, effectively preventing its interaction with downstream effectors that are critical for actin filament organization. This unique inhibitory capability makes EHT 1864 an invaluable tool in cellular biology and molecular research, as it allows for the precise dissection of Rac1-mediated signaling pathways. Researchers leverage EHT 1864 to unravel the complex roles of Rac1 in various cellular processes, including cell motility, adhesion, and proliferation, providing insights into the fundamental mechanisms that underpin cellular behavior and response to external stimuli. Its specificity and potency are instrumental in studying the nuanced roles of Rac1, facilitating advancements in our understanding of cytoskeletal organization and its implications for cell physiology.