Molecular structure of EHNA hydrochloride, CAS Number: 51350-19-7
EHNA hydrochloride (CAS 51350-19-7)
See product citations (6)
Alternate Names:
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, (αR,βS)-rel-6-amino-β-hexyl-α-methyl-9H-purine-9-ethanol, monohydrochloride
Application:
EHNA hydrochloride is an inhibitor of adenosine deaminase and cyclic nucleotide PDE2 (phosphodiesterase- 2)
CAS Number:
51350-19-7
Purity:
≥98%
Molecular Weight:
313.83
Molecular Formula:
C14H23N5O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SDS & Certificate of Analysis
EHNA hydrochloride acts as an inhibitor of adenosine deaminase (ADA) and as a selective inhibitor of cyclic nucleotide PDE2 (phosphodiesterase- 2). EHNA hydrochloride has been used to investigate the protective response of adenosine in myocardial cell studies in vitro, and to understand the role that the adenosine pathway plays in heart studies. Urinary bladder studies in vitro show that EHNA hydrochloride blocks the ATPase and motor activities of cytoplasmic dynein in vitro and cardiac myocyte studies show EHNA hydrochloride to block the activity of cGMP-stimulated phosphodiesterase.
EHNA hydrochloride (CAS 51350-19-7) References
- Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate. | Uckert, S., et al. 2001. J Urol. 166: 2484-90. PMID: 11696815
- Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. | Hattori, H., et al. 2010. Proc Natl Acad Sci U S A. 107: 3546-51. PMID: 20142487
- Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. | Burton, P., et al. 2010. Biochem J. 432: 575-84. PMID: 20923411
- Susceptibility of Trypanosoma evansi to cordycepin. | Da Silva, AS., et al. 2011. Biomed Pharmacother. 65: 220-3. PMID: 21620640
- PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis. | Bernard, JJ., et al. 2014. PLoS One. 9: e109862. PMID: 25330380
- Simultaneous Quantification of Methylated Cytidine and Adenosine in Cellular and Tissue RNA by Nano-Flow Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method. | Fu, L., et al. 2015. Anal Chem. 87: 7653-9. PMID: 26158405
- Inhibition of adenosine deaminase from several sources by deaza derivatives of adenosine and EHNA. | Lupidi, G., et al. 1985. J Enzyme Inhib. 1: 67-75. PMID: 3916912
- Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes. | Méry, PF., et al. 1995. Mol Pharmacol. 48: 121-30. PMID: 7623766
- Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine. | Podzuweit, T., et al. 1995. Cell Signal. 7: 733-8. PMID: 8519602
- Effect of a dynein inhibitor on vasopressin action in toad urinary bladder. | Marples, D., et al. 1996. J Physiol. 490 (Pt 3): 767-74. PMID: 8683474
- Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. | Michie, AM., et al. 1996. Cell Signal. 8: 97-110. PMID: 8730511
- Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium. | Mallet, RT., et al. 1996. Cardiovasc Res. 31: 102-16. PMID: 8849594
- AMP degradation in the perfused rat heart during 2-deoxy-D-glucose perfusion and anoxia. Part II: The determination of the degradation pathways using an adenosine deaminase inhibitor. | Chen, W. and Guéron, M. 1996. J Mol Cell Cardiol. 28: 2175-82. PMID: 8930812
- Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats. | Woodson, JC., et al. 1998. Behav Neurosci. 112: 399-409. PMID: 9588486
Inhibitor of:
Adenosine deaminase, PDE, and PDE1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EHNA hydrochloride, 10 mg | sc-201184 | 10 mg | $102.00 | |||
EHNA hydrochloride, 50 mg | sc-201184A | 50 mg | $372.00 |