EGTA tetrasodium (CAS 13368-13-3)
QUICK LINKS
EGTA tetrasodium is a chelating agent that plays a role in cellular and molecular biology by binding to divalent cations such as calcium and magnesium. Its mechanism of action involves the formation of stable complexes with these cations, effectively sequestering them and preventing their participation in various cellular processes. This chelating property makes EGTA tetrasodium useful in laboratory, particularly in the study of calcium-dependent processes within cells. By chelating calcium ions, EGTA tetrasodium can disrupt signaling pathways that rely on calcium, such as muscle contraction, neurotransmitter release, and gene expression. It can be used to remove extracellular calcium, which is essential for studying the role of calcium in cell adhesion and migration. EGTA tetrasodium is utilized in the isolation of intracellular organelles, as it can disrupt the integrity of cell membranes by chelating the calcium ions that help maintain their structure. The chelating properties of EGTA tetrasodium make it indispensable for investigating the role of calcium in various cellular processes and pathways.
EGTA tetrasodium (CAS 13368-13-3) References
- Synthetic phosphoantigens enhance human Vgamma9Vdelta2 T lymphocytes killing of non-Hodgkin's B lymphoma. | Sicard, H., et al. 2001. Mol Med. 7: 711-22. PMID: 11713370
- Development and characterization of secretin-stimulated secretion of cultured rat cholangiocytes. | Alpini, G., et al. 2003. Am J Physiol Gastrointest Liver Physiol. 284: G1066-73. PMID: 12540366
- Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. | Ling, TY., et al. 2004. J Biol Chem. 279: 38736-48. PMID: 15226301
- Ketamine-induced cardiac depression is associated with increase in [Mg2+]i and activation of p38 MAP kinase and ERK 1/2 in guinea pig. | Kim, SJ., et al. 2006. Biochem Biophys Res Commun. 349: 716-22. PMID: 16945337
- Efficient strontium-induced activation of mouse oocytes in standard culture media by chelating calcium. | Kishigami, S. and Wakayama, T. 2007. J Reprod Dev. 53: 1207-15. PMID: 17938555
- PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors. | Melis, M., et al. 2013. J Neurosci. 33: 6203-11. PMID: 23554501
- Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels. | Naik, JS., et al. 2016. Am J Physiol Heart Circ Physiol. 311: H1437-H1444. PMID: 27765747
- Cocaine Selectively Reorganizes Excitatory Inputs to Substantia Nigra Pars Compacta Dopamine Neurons. | Beaudoin, GMJ., et al. 2018. J Neurosci. 38: 1151-1159. PMID: 29263240
- Derivation and maintenance of mouse haploid embryonic stem cells. | Elling, U., et al. 2019. Nat Protoc. 14: 1991-2014. PMID: 31160788
- Population Kinetics and Mechanistic Aspects of Saccharomyces cerevisiae Growth in Relation to Selenium Sulfide Nanoparticle Synthesis. | Asghari-Paskiabi, F., et al. 2020. Front Microbiol. 11: 1019. PMID: 32508800
- Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems. | Burkard, T., et al. 2022. Cells. 11: PMID: 35326378
- X-ray absorption microscopy of aqueous samples | Brad Frazer, Benjamin Gilbert and Gelsomina De Stasio. 2002. Review of Scientific Instruments. Volume 73, Issue 3: 1373.
- Peptide-functionalized carbon dots for sensitive and selective Ca2+ detection | Yuchen Lin, Yongfang Zheng, Yichuan Guo, Yanlian Yang, Hongbian Li, Ying Fang, Chen Wang. 2018. Sensors and Actuators B: Chemical. Volume 273: 1654-1659.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EGTA tetrasodium, 10 g | sc-252773 | 10 g | $120.00 | |||
EGTA tetrasodium, 50 g | sc-252773A | 50 g | $300.00 |