Molecular structure of EGTA/AM, CAS Number: 99590-86-0
EGTA/AM (CAS 99590-86-0)
See product citations (4)
Alternate Names:
Ethyleneglycol-bis(β-aminoethyl)-N,N,N′,N′-tetraacetoxymethyl Ester
Application:
EGTA/AM is a membrane-permeable form of the EGTA Ca2+-chelating agent
CAS Number:
99590-86-0
Purity:
≥90%
Molecular Weight:
668.6
Molecular Formula:
C26H40N2O18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
EGTA/AM is a membrane-permeable form of the EGTA Ca2+-chelating agent. EGTA acetoxymethyl ester (EGTA-AM) is an organic compound that finds extensive use in diverse scientific research applications. It is a derivative of ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA) and serves as useful in laboratory experiments. One of its prominent applications lies in the investigation of calcium ions′ impact on cellular processes, owing to its ability to chelate calcium ions and modulate their concentrations within the cell. Moreover, EGTA-AM is employed to explore cell membrane potentials by binding to the cell membrane and influencing its permeability. Furthermore, it enables the study of calcium ions′ effects on cell metabolism and enzyme activity, providing insights into cellular mechanisms.
EGTA/AM (CAS 99590-86-0) References
- Cooling and freezing damage platelet membrane integrity. | Reid, TJ., et al. 1999. Cryobiology. 38: 209-24. PMID: 10328911
- The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. | Pryor, PR., et al. 2000. J Cell Biol. 149: 1053-62. PMID: 10831609
- A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. | Hardingham, GE., et al. 2001. Nat Neurosci. 4: 565-6. PMID: 11369935
- Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. | Gong, G., et al. 2001. Proc Natl Acad Sci U S A. 98: 9599-604. PMID: 11481452
- Heat stress-activated, calcium-dependent nitric oxide synthase in sponges. | Giovine, M., et al. 2001. Nitric Oxide. 5: 427-31. PMID: 11587557
- Effect of thrombopoietin alone and a combination of cytochalasin B and ethylene glycol bis(beta-aminoethyl ether) N,N'-tetraacetic acid-AM on the survival and function of autologous baboon platelets stored at 4 degrees C for as long as 5 days. | Valeri, CR., et al. 2004. Transfusion. 44: 865-70. PMID: 15157253
- Synaptic mechanisms of persistent reverberatory activity in neuronal networks. | Lau, PM. and Bi, GQ. 2005. Proc Natl Acad Sci U S A. 102: 10333-8. PMID: 16006530
- Reliable long-lasting depression interacts with variable short-term facilitation to determine corticostriatal paired-pulse plasticity in young rats. | Akopian, G. and Walsh, JP. 2007. J Physiol. 580: 225-40. PMID: 17234703
- Thrombin potently enhances swelling-sensitive glutamate efflux from cultured astrocytes. | Ramos-Mandujano, G., et al. 2007. Glia. 55: 917-25. PMID: 17437307
- The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. | Tang, Q., et al. 2007. Biochem Pharmacol. 74: 1596-607. PMID: 17826747
- Increase in cytosolic calcium maintains plasma membrane integrity through the formation of microtubule ring structure in apoptotic cervical cancer cells induced by trichosanthin. | Wang, P., et al. 2009. Cell Biol Int. 33: 1149-54. PMID: 19706333
- Depolarization-induced calcium-independent synaptic vesicle exo- and endocytosis at frog motor nerve terminals. | Abdrakhmanov, MM., et al. 2013. Acta Naturae. 5: 77-82. PMID: 24455186
- Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging. | Ouanounou, A., et al. 1999. J Neurosci. 19: 906-15. PMID: 9920654
- Involvement of intracellular calcium in morphine tolerance in mice. | Smith, FL., et al. 1999. Pharmacol Biochem Behav. 62: 381-8. PMID: 9972707
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EGTA/AM, 10 mg | sc-203937 | 10 mg | $267.00 |