Molecular structure of EGTA, CAS Number: 67-42-5
EGTA (CAS 67-42-5)
See product citations (23)
Alternate Names:
EGTA is also known as Ethylene Glycol Tetraacetic Acid.
Application:
EGTA is a chelator with specificity for calcium ions used to determine calcium in the presence of magnesium.
CAS Number:
67-42-5
Purity:
≥97%
Molecular Weight:
380.35
Molecular Formula:
C14H24N2O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
EGTA is a useful chemical in a variety of buffers, EGTA is a chelating agent useful for the determination of calcium in the presence of magnesium, since EGTA has greater specificity for calcium ions. Inhibitor of alkaline phosphatase activity which is useful in ELISA reactions. EGTA is shown to activate Ca2+-stimulated ATPase in rat liver plasma membranes and induce apoptosis in PC12 cells. It also inhibits the zinc-dependent endopeptidases, Matrix metalloproteinases (MMPs).
EGTA (CAS 67-42-5) References
- A test to evaluate the effect of individual components of ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid buffers on enzymatic activity. | Vidal, H., et al. 1991. Anal Biochem. 193: 135-41. PMID: 1645932
- Rapid and extensive release of Ca2+ from energized mitochondria induced by EGTA. | Riley, WW. and Pfeiffer, DR. 1986. J Biol Chem. 261: 28-31. PMID: 2416747
- Effects of chelating agents on the Ca2+-stimulated ATPase of rat liver plasma membranes. | Birch-Machin, MA. and Dawson, AP. 1986. Biochim Biophys Acta. 855: 277-85. PMID: 2936394
- Effects of calcium-binding sites in the S2-S3 loop on human and Nematostella vectensis TRPM2 channel gating processes. | Luo, YH., et al. J Zhejiang Univ Sci B. 20: 972-982. PMID: 31749344
- Annexin A2 Flop-Out Mediates the Non-Vesicular Release of DAMPs/Alarmins from C6 Glioma Cells Induced by Serum-Free Conditions. | Matsunaga, H., et al. 2021. Cells. 10: PMID: 33807671
- Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy. | Palikaras, K., et al. 2021. Aging (Albany NY). 13: 23876-23894. PMID: 34751671
- Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells. | Kadir, RRA., et al. 2022. Metab Brain Dis. 37: 1815-1827. PMID: 35763197
- PLXND1-mediated calcium dyshomeostasis impairs endocardial endothelial autophagy in atrial fibrillation. | Sun, M., et al. 2022. Front Physiol. 13: 960480. PMID: 36017337
- Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model. | Wu, CT., et al. 2022. Molecules. 27: PMID: 36144517
- Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis. | Zai, Z., et al. 2022. J Transl Med. 20: 561. PMID: 36463203
- Cathelicidin Attenuates Hyperoxia-Induced Lung Injury by Inhibiting Ferroptosis in Newborn Rats. | Chou, HC. and Chen, CM. 2022. Antioxidants (Basel). 11: PMID: 36552613
- Structure-Activity Relationships of RGD-Containing Peptides in Integrin αvβ5-Mediated Cell Adhesion. | Yamada, Y., et al. 2023. ACS Omega. 8: 4687-4693. PMID: 36777587
- Use of chelating agents as terminators of alkaline phosphatase activity in enzyme-linked immunosorbent assay (ELISA) tests. | Brauner, P. and Fridlender, B. 1981. J Immunol Methods. 42: 375-9. PMID: 6270211
- Inhibition of drug-induced apoptosis by survival factors in PC12 cells. | Lindenboim, L., et al. 1995. J Neurochem. 64: 1054-63. PMID: 7861134
Inhibitor of:
3110007F17Rik, 4922502D21Rik, 4930412D23Rik, 4930468A15Rik, 4931429I11Rik, 5 alpha-Reductase 1, ADH6A, Annexin A9, Annexin IV, Annexin XI, APBA2BP, ARA160, ARL8, AY026312, BR-cadherin, CaBP7, CABYR, cadherin-16, cadherin-20, cadherin-26, cadherin-28, cadherin-29, cadherin-7, Calbindin D28K, Calmegin, Calumenin, CDH20, CEACAM16, Centrin, Centrin-3, Claudin (CLDN), claudin-12, claudin-19, Clusterin-L1, copine 1, copine 6, copine 9, CUTA, DHDPSL, DHRS1, DOC2A, EF-CBP2, EG238829, EG331493, EG546400, Enzyme, FAM114A2, ficolin A, ficolin B, GEN1, Gm281, Gm5849, Hen Egg Lysozyme, Integrin αE, IP6K1, L-ficolin, MMP, NELL1, Nephrocalcin, Occludin, Olfr370, Olfr44, Olfr444, Olfr462, Olfr750, Olfr9, Otoconin 90, PC-LKC, PCDH2, PCDH20_Pcdh20, PCDHA13, PCDHA4, PCDHA6, PCDHA7, PCDHA8, PCDHA9, PCDHB14, PCDHB8, PCDHB9, PCDHGB2, PEPD, PPA2, PRRG1, PRRG2, rabphilin-3AL, reticulocalbin-3, S-100, Snapin, Synaptotagmin IV, Synaptotagmin V, Synaptotagmin VII, T1-cadherin, TATDN2, TGase5, Tuftelin, UCMA, V1RG4, V1RG5, V1RG6, V1RH2, V1RH4, VWA8, ZIP14, ZnT-1, and ZP4.Activator of:
Annexin VII, Annexin VIII, ANXA8L1, AP1S3, Bestrophin-1, Bestrophin-3, C1r, C1rb, C5β, CaBP4, Calgranulin C, CALHM1, CALM, CALR3, Calretinin, CaMKKβ, CBARA1, CHERP, CHP, CHP2, claudin-3, CWC22, cyclin M1, Cyclosporin A, D630042P16Rik, DNA pol γ, EF-CAB1, EF-CAB2, GCP4, Gm5849, Grancalcin, GTPBP4, IBA2, IP3KC, IQCC, IQCJ, KDEL receptor 3, LOC85449, LRRC18, nephrocystin-2, NOXO1, OTTMUSG00000008561, P4H-TM, PCDH7, PEF, PMCA4b, PPEF-1, PPEF-2, PRODH2, Rab 41, S-100A5, Sec23IP, SEC24A, SLC26A10, SPPase1, Synaptogyrin-2, Synaptotagmin III, Synaptotagmin VI, Synaptotagmin X, Synaptotagmin XI, Tesp2, TESSP-1, TMP21, TorsinB, Trypsin-10, Trypsin-4, WDR85, ZIM1, and zinedin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EGTA, 1 g | sc-3593 | 1 g | $20.00 | |||
EGTA, 10 g | sc-3593A | 10 g | $62.00 | |||
EGTA, 100 g | sc-3593B | 100 g | $116.00 | |||
EGTA, 250 g | sc-3593C | 250 g | $246.00 | |||
EGTA, 1 kg | sc-3593D | 1 kg | $799.00 |