Molecular structure of EGFR Inhibitor, CAS Number: 879127-07-8
EGFR Inhibitor Inhibitor (CAS 879127-07-8)
Alternate Names:
Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide
Application:
EGFR Inhibitor is a highly selective, cell-permeable EGFR inhibitor
CAS Number:
879127-07-8
Molecular Weight:
413.4
Molecular Formula:
C21H18F3N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
EGFR Inhibitor is a cell permeable compound that is a highly selective inhibitor of EGFR (epidermal growth factor receptor). Inhibition of EGFR may act to induce apoptosis. EGFR inhibition takes place via downregulation of antiapoptotic protein survivin expression. Downregulation of Survivin has been observed to take place following inhibition of the PI3K-AKT signaling pathway. Additional experiments report that EGFR inhibitor also induces upregulation of proapoptotic protein BIM.
EGFR Inhibitor Inhibitor (CAS 879127-07-8) References
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- Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. | Saito, K., et al. 2013. PLoS One. 8: e54853. PMID: 23349978
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- Peptide ligand-mediated endocytosis of nanoparticles to cancer cells: Cell receptor-binding- versus cell membrane-penetrating peptides. | Jo, E., et al. 2018. Biotechnol Bioeng. 115: 1437-1449. PMID: 29460954
- Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis. | Hardesty, JE., et al. 2019. J Proteome Res. 18: 1582-1594. PMID: 30807179
- Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. | Nanjo, S., et al. 2022. J Clin Invest. 132: PMID: 35579943
- A New EGFR Inhibitor from Ficus benghalensis Exerted Potential Anti-Inflammatory Activity via Akt/PI3K Pathway Inhibition. | Alaaeldin, R., et al. 2022. Curr Issues Mol Biol. 44: 2967-2981. PMID: 35877429
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- Fusion Gene Detection in Prostate Cancer Samples Enhances the Prediction of Prostate Cancer Clinical Outcomes from Radical Prostatectomy through Machine Learning in a Multi-Institutional Analysis. | Yu, YP., et al. 2023. Am J Pathol. 193: 392-403. PMID: 36681188
Inhibitor of:
EGFR, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EGFR Inhibitor, 1 mg | sc-203934 | 1 mg | $219.00 |