Molecular structure of EGFR/ErbB-2 Inhibitor, CAS Number: 179248-61-4
EGFR/ErbB-2 Inhibitor Inhibitor (CAS 179248-61-4)
Application:
EGFR/ErbB-2 Inhibitor is a potent reversible inhibitor of EGFR and c-erbB2
CAS Number:
179248-61-4
Purity:
>97%
Molecular Weight:
387.4
Molecular Formula:
C23H21N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
The EGFR/ErbB-2 Inhibitor represents a class of compounds pivotal in the realm of molecular biology and oncology research, specifically targeting the epidermal growth factor receptor (EGFR) and the ErbB-2 receptor (HER2/neu). These receptors play roles in cellular signaling pathways that regulate cell proliferation, survival, adhesion, migration, and differentiation, all of which are fundamental processes in the development and progression of tumors. The mechanism of action involves the blockade of tyrosine kinase activity, which is essential for the activation of downstream signaling cascades that promote oncogenesis.
EGFR/ErbB-2 Inhibitor Inhibitor (CAS 179248-61-4) References
- Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling. | Weng, MS., et al. 2007. Toxicol Appl Pharmacol. 218: 107-18. PMID: 17182072
- ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. | Osipo, C., et al. 2008. Oncogene. 27: 5019-32. PMID: 18469855
- Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines. | Hubbard, RD., et al. 2008. Bioorg Med Chem Lett. 18: 5738-40. PMID: 18842405
- Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors. | Rheault, TR., et al. 2009. Bioorg Med Chem Lett. 19: 817-20. PMID: 19111461
- Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors. | Waterson, AG., et al. 2009. Bioorg Med Chem Lett. 19: 1332-6. PMID: 19208477
- Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery. | Liu, J., et al. 2019. IEEE Trans Biomed Eng. 66: 1231-1241. PMID: 30235116
Inhibitor of:
EGFR, and Neu.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EGFR/ErbB-2 Inhibitor, 1 mg | sc-203935 | 1 mg | $101.00 |