Molecular structure of Eg5 Inhibitor VII, CAS Number: 912953-25-4
Eg5 Inhibitor VII (CAS 912953-25-4)
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Alternate Names:
KSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone, GSK-1
Application:
Eg5 Inhibitor VII is a very potent and selective Eg5/KSP inhibitor
CAS Number:
912953-25-4
Molecular Weight:
291.3
Molecular Formula:
C16H12F3NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Eg5 Inhibitor VII is a cell-permeable quinolinone compound that acts as a very potent and selective Eg5/KSP inhibitor by antagonizing ATP binding via an allosteric site. Eg5 Inhibitor VII effectively induces monopolar spindles in ovarian adenocarcinoma SKOV3 cells, and inhibits the proliferation of colorectal carcinoma HCT116 cells. Eg5 Inhibitor VII is not competitive with respect to microtubule and exhibits minimal activity against a panel of 7 other mitotic kinesins.
Eg5 Inhibitor VII (CAS 912953-25-4) References
- ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. | Luo, L., et al. 2007. Nat Chem Biol. 3: 722-6. PMID: 17922005
Inhibitor of:
ATPase, and Eg5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eg5 Inhibitor VII, 5 mg | sc-221578 | 5 mg | $156.00 |