Eg5 Inhibitor V, trans-24 CAS: 869304-55-2
MF: C26H21N3O3
MW: 423.5
A cell-permeable potent against mitotic kinesin Eg5-ATPase activity.

Eg5 Inhibitor V, trans-24 (CAS 869304-55-2)

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Alternate Names: (5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-6H-1,2,3,5,11,11a-hexahydroimidazo[1,5-b]-β-carboline-1,3-dione
Application: Eg5 Inhibitor V, trans-24 is a cell-permeable potent against mitotic kinesin Eg5-ATPase activity
CAS Number: 869304-55-2
Molecular Weight: 423.5
Molecular Formula: C26H21N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Eg5 Inhibitor V, trans-24 is a cell-permeable HR22C16 derivative that exhibits much enhanced potency against mitotic kinesin Eg5-ATPase activity (IC50 = 0.65 vs. 4.3 µM for trans-24 and HR22C16, respectively) and little or no activity against 9 other kinesins. Shown to induce monoastral phenotype in HeLa cells (20 µM).


References

Sunder-Plassmann, N., et al. 2005. Bioorg. Med. Chem. 13, 6094.

Physical State :
Solid
Solubility :
DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11553595
SMILES :
Oc1cccc(c1)[[email protected]]1N2C(=O)N(Cc3ccccc3)C(=O)[[email protected]@H]2Cc2c1[nH]c1ccccc21

Download SDS (MSDS)

Certificate of Analysis

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