Date published: 2025-10-8

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Eg5 Inhibitor IV, VS-83 (CAS 909250-29-9)

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Application:
Eg5 Inhibitor IV, VS-83 is an inhibitor of mitotic kinesin Eg5-ATPase activity
CAS Number:
909250-29-9
Purity:
≥99%
Molecular Weight:
274.3
Molecular Formula:
C14H11FN2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Eg5 Inhibitor IV, VS-83 is a cell-permeable Monastrol analog with enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Exhibits ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Eg5 Inhibitor IV, VS-83, 5 mg

sc-203933
5 mg
$480.00